An 8-month-old infant presented with chronic diarrhea, persistent right ear discharge, oral candidiasis responding poorly to antifungal drugs, and failure to thrive. On examination the infant has exfoliative erythroderma, lymphadenopathy, and hepatosplenomegaly. Peripheral blood showed eosinophilia and elevated IgE. The parents are young first cousin and he is their first baby. Of the following, the MOST likely diagnosis is

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Pediatric Immunizations NCLEX Questions Questions

Question 1 of 5

An 8-month-old infant presented with chronic diarrhea, persistent right ear discharge, oral candidiasis responding poorly to antifungal drugs, and failure to thrive. On examination the infant has exfoliative erythroderma, lymphadenopathy, and hepatosplenomegaly. Peripheral blood showed eosinophilia and elevated IgE. The parents are young first cousin and he is their first baby. Of the following, the MOST likely diagnosis is

Correct Answer: C

Rationale: Omenn syndrome, a form of SCID, presents with erythroderma, eosinophilia, and elevated IgE due to consanguinity-related genetic defects.

Question 2 of 5

When we inhibit alternative pathway convertase, all of the following would decrease EXCEPT

Correct Answer: C

Rationale: The alternative pathway involves C3b and does not form C4b2b, which is specific to the classical/lectin pathways, so inhibiting it would not affect C4b2b levels.

Question 3 of 5

Which of the following is a soluble pattern recognition receptor

Correct Answer: C

Rationale: Pentraxin 3 is a soluble pattern recognition receptor in the innate immune system, unlike the others which are membrane-bound or intracellular.

Question 4 of 5

long statements about Kidney transplant that has been rejected within minutes, choose the wrong statement

Correct Answer: C

Rationale: Hyperacute rejection occurs within minutes due to preformed antibodies, not donor APCs, which are involved in acute/chronic rejection. Answer assumed as C based on context.

Question 5 of 5

Which of the following isn't true about Allograft rejection

Correct Answer: A

Rationale: Allograft rejection involves recognition of donor MHC (alloantigens), not DAMPs, by recipient lymphocytes.

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