ATI RN
Pediatric Immunization NCLEX Questions Ricci Questions
Question 1 of 5
Allelic exclusion is a process by which the protein from only one allele is expressed while other allele(s) are silenced. Allelic exclusion occurs (generally) in which of the following?
Correct Answer: A
Rationale: Allelic exclusion occurs in B cells and TCR beta chains, but not typically in alpha chains.
Question 2 of 5
Because of a lack of genetic recombination in the MHC, blocks of alleles (haplotypes) are inherited together, and they are identical in families. Which of the following is the likely result of this?
Correct Answer: A
Rationale: Identical HLA haplotypes in families simplify tissue transplantation due to matched alleles.
Question 3 of 5
Multiple sclerosis
Correct Answer: B
Rationale: Multiple sclerosis is associated with HLA-DR2.
Question 4 of 5
generated in vesicles (extracellular infection, e.g. bacteria) bind to MHC molecules for presentation to T cells.
Correct Answer: B
Rationale: Extracellular antigens (e.g., bacteria) are processed in vesicles and presented by MHC Class II to CD4+ T cells, while intracellular antigens are presented by MHC Class I to CD8+ T cells.
Question 5 of 5
Immunoreceptor tyrosine-based activation motifs (ITAMs) are essential for signal transduction in cells.
Correct Answer: D
Rationale: ITAMs are critical for signal transduction in both B cells (via BCR) and T cells (via TCR).