ATI RN
Pediatric Immunization Practice Questions Questions
Question 1 of 5
Allelic exclusion creates monospecific B-cell receptors (BCRs). The result is these cells each secrete:
Correct Answer: D
Rationale: Allelic exclusion ensures each B cell produces antibodies with one specificity.
Question 2 of 5
Activation of a T cell requires ___. Following activation, the T cell proliferates and differentiates into ___, then moves into peripheral tissues and other organs.
Correct Answer: D
Rationale: T-cell activation requires both MHC-antigen recognition and costimulation, leading to effector cell differentiation.
Question 3 of 5
What is the immunologic consequence of mutation in CD40L (CD154)?
Correct Answer: C
Rationale: CD40L mutation causes X-linked hyper-IgM syndrome, impairing class switching from IgM.
Question 4 of 5
The route of antigen processing (cytosolic versus vesicle bound) determines whether an antigen is presented by MHC class II molecules to a TCR on a CD4+ helper (TH) cell, or by major histocompatibility complex (MHC) class I molecules to a TCR on a CD8+ cytotoxic T cell.
Correct Answer: A
Rationale: Cytosolic antigens go to MHC I (CD8+), vesicle-bound to MHC II (CD4+). This is true.
Question 5 of 5
Secrete cytokines if damaged
Correct Answer: D
Rationale: Living skin keratinocytes secrete cytokines when damaged as an innate response.