All the following uses are shared by both aspirin and celecoxib EXCEPT

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Benzylpenicillin is effective in meningococcal infections (B) because it has potent activity against Neisseria meningitidis, making it a key treatment for meningococcal meningitis and septicaemia. It's administered parenterally due to inactivation by gastric acid (A), which hydrolyzes its beta-lactam ring, but this isn't the primary focus. Its half-life is approximately 30-60 minutes, not 24 hours (C), due to rapid renal elimination, requiring frequent dosing or continuous infusion in severe cases. It's more susceptible to beta-lactamases than flucloxacillin (D), which is specifically designed to resist these enzymes produced by staphylococci. Benzylpenicillin's efficacy in meningococcal disease stems from its ability to penetrate the cerebrospinal fluid (CSF) during inflammation and its bactericidal action against Gram-positive and select Gram-negative bacteria, though its use is limited by resistance in other pathogens.

Correct Answer: B

Rationale: Erythromycin has a shorter half-life than azithromycin (B), approximately 1-2 hours versus 68 hours, requiring more frequent dosing. It's well absorbed orally (A is incorrect), though food can reduce bioavailability, and IV forms are used for severe infections. The most common adverse effect is gastrointestinal upset (nausea, diarrhea), not headache (C). It inhibits CYP450 enzymes (D), notably CYP3A4, causing drug interactions (e.g., with statins). It can be prescribed with amoxicillin (original E is incorrect) if clinically indicated. Erythromycin's macrolide action targets protein synthesis in Gram-positive and atypical bacteria, but its shorter half-life and GI side effects often make newer macrolides like azithromycin preferable in outpatient settings.

Correct Answer: A

Rationale: Peripheral neuropathy paired with isoniazid (A) is correct, caused by pyridoxine (vitamin B6) depletion, preventable with supplementation, common in slow acetylators. Ototoxicity (B) is linked to streptomycin, not rifampicin, which causes hepatotoxicity. Hyperuricaemia (C) with pyrazinamide is accurate, due to uric acid retention, risking gout. Retrobulbar neuritis (D) with ethambutol is correct, affecting optic nerve function, necessitating vision monitoring. Hepatotoxicity with streptomycin (original E) is incorrect; it's more associated with isoniazid or rifampicin. Isoniazid's neurotoxicity reflects its interference with pyridoxal phosphate, critical for nerve function, making pyridoxine co-administration standard in TB regimens to mitigate this frequent, dose-related side effect.