All the following are true regarding diazepam in neonatal seizurEXCEPT

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Pediatric Neurology Practice Questions Questions

Question 1 of 5

All the following are true regarding diazepam in neonatal seizurEXCEPT

Correct Answer: B

Rationale: Diazepam is lipophilic, aiding brain penetration, and has higher seizure recurrence due to short duration. It risks apnea and hypotension in neonatand is not first-line (E is false as stated). However, it is not cleared quickly ; neonathave immature liver metabolism, prolonging its half-life (up to 50-100 hours), unlike adults. This slow clearance increastoxicity risk, making B the exception and correct answer, as it contradicts diazepams pharmacokinetics in neonates.

Question 2 of 5

The following are manifestations of increased intracranial pressure in an infant EXCEPT

Correct Answer: C

Rationale: Increased intracranial pressure (ICP) in infants caushead circumference growth , bulging fontanel , vomiting , and setting sun sign due to CSF or mass effects. Failure to thrive is not a direct sign; it may occur secondary to chronic illness but isnt specific to ICP. This distinction direct pressure signs versus systemic effects makes C the exception and correct answer.

Question 3 of 5

A premature infant blinks in response to a bright light at

Correct Answer: C

Rationale: Premature infants blink to light by 30 weeks corrected gestational age , as the pupillary reflex matur(Volpe). Earlier (26-28 weeks, A-B) lacks this response; later (32-34 weeks) is typical for term infants. This neurologic milestone 30 weeks makes C the correct answer, reflecting ocular development.

Question 4 of 5

In patients with febrile seizures, one of the following risk factors has the highest risk for subsequent epilepsy

Correct Answer: C

Rationale: Neurodevelopmental abnormalitipose the highest epilepsy risk (~30-50%) after febrile seizures, indicating underlying brain dysfunction. Recurrent seizur, short fever onset , family history , and complex seizurhave lower risks (~5-15%). Structural or functional brain issudrive C as the correct answer.

Question 5 of 5

Drug therapy should be based on the type of seizure and the epilepsy syndrome as well as on other individual factors. Of the following, the drug of first choice for focal seizurand epilepsiis

Correct Answer: A

Rationale: Carbamazepine is the first-line drug for focal seizures, per ILAE, due to its sodium channel blockade targeting partial-onset epilepsy. Ethosuximide treats absence seizures, valproate generalized seizures, and lamotrigine is adjunctive. Carbamazepinefficacy and evidence base make A the correct answer.

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