All of the following statements concerning drugs which inhibit cholesterol synthesis are true, EXCEPT:

Correct Answer: D

Rationale: The correct answer is D. Drugs that inhibit cholesterol synthesis, such as statins, do not tend to lengthen the sleep cycle. Statins are not known to have a direct effect on sleep patterns. Choices A, B, and C are true statements regarding drugs inhibiting cholesterol synthesis. Choice A is correct as these drugs are contraindicated in pregnant women and children due to potential harm to fetal development. Choice B is correct as statins can cause myopathy, especially when used with cyclosporine. Choice C is correct as failure to discontinue the drug after myopathy has been detected can lead to acute renal failure.

Correct Answer: D

Rationale: The correct answer is D: Fractures. Plicamycin is not known to cause fractures. Thrombocytopenia, GI toxicity, and bleeding disorders are potential unwanted effects of plicamycin due to its impact on bone marrow and gastrointestinal tract. It is crucial to recognize that fractures are not a documented side effect of plicamycin, making option D the correct answer.

Correct Answer: D

Rationale: Rationale: 1. Choice A is correct because combining antimicrobial agents can enhance their effectiveness against resistant strains. 2. Choice B is correct because a combination can target a wider range of microorganisms. 3. Choice C is correct because using a combination can help reduce the chance of resistance developing. Summary: All of the above choices are correct because rational antimicrobial combinations provide synergism, broad coverage, and prevent resistance emergence.

Correct Answer: C

Rationale: The correct answer is C: "Does not demonstrate nephrotoxicity." Amphotericin B is known for its nephrotoxicity, which can lead to kidney damage. This is a well-documented side effect of the drug. Choices A, B, and D are incorrect because Amphotericin B is indeed used for systemic mycosis treatment, poorly absorbed from the gastrointestinal tract, and influences the permeability of fungus cell membrane, making them true characteristics of the drug.

Correct Answer: B

Rationale: Step 1: Tetracyclins are known to have antimalarial properties by inhibiting protein synthesis in Plasmodium species. Step 2: Aminoglycosides (choice A) primarily target bacteria, not parasites like malaria. Step 3: Carbapenems (choice C) and Penicillins (choice D) are both beta-lactam antibiotics that have no significant antimalarial effects. Summary: Tetracyclins are the correct choice as they directly target malaria parasites, while the other options do not possess antimalarial properties.