All of the following drugs are immune checkpoint inhibitors for treatment of metastatic renal cell carcinoma, Except:

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Question 1 of 5

All of the following drugs are immune checkpoint inhibitors for treatment of metastatic renal cell carcinoma, Except:

Correct Answer: A

Rationale: Bevacizumab is a VEGF inhibitor blocks angiogenesis, not an immune checkpoint inhibitor (e.g., PD-1/CTLA-4). Pembrolizumab, Ipilimumab, and Nivolumab target immunity enhance T-cell response in metastatic RCC. Bevacizumab's vascular mechanism distinguishes it, critical for differentiating therapies, unlike immune-boosting drugs.

Question 2 of 5

Which of the following is unlikely to recur in transplant kidney?

Correct Answer: A

Rationale: ADPKD doesn't recur in transplants native cysts remain, new kidney unaffected (genetic, not systemic). Hyperoxaluria type 1 recurs oxalate damages graft. Atypical HUS (complement) can relapse systemic. Glomerulonephritis (e.g., IgA) often returns immune-driven. ADPKD's non-recurrence distinguishes it, critical for transplant prognosis, unlike systemic or immune risks.

Question 3 of 5

Absolute contraindications for paediatric renal transplant include all except

Correct Answer: B

Rationale: Uncontrolled infection isn't absolute treatable, transplant possible post-resolution in kids. Uncontrolled malignancy halts transplant active disease risk. ABO incompatibility and positive crossmatch are absolute rejection barriers. Infection's treatability distinguishes it, critical for pediatric candidacy, unlike permanent or immunologic blocks.

Question 4 of 5

Clinical findings that may suggest presence of DSD in a boy include the following except

Correct Answer: D

Rationale: Inguinal hernia before 6 months is common doesn't suggest DSD (disorder of sex development). Delayed puberty (gonadal dysfunction), cyclical haematuria (e.g., uterine remnant), and hypospadias with cryptorchidism (ambiguous genitalia) hint at DSD genetic/hormonal issues. Hernia's normalcy distinguishes it, key to excluding routine findings, unlike DSD-linked anomalies.

Question 5 of 5

The alpha blocker with least adverse effect on ejaculatory function is

Correct Answer: B

Rationale: Alfuzosin minimally affects ejaculatory function less selective for alpha-1a receptors in seminal vesicles/prostate, reducing retrograde ejaculation risk. Tamsulosin and silodosin, highly alpha-1a selective, disrupt emission common side effect. Naftopidil (less studied) also impacts ejaculation similar selectivity. Alfuzosin's broader profile distinguishes it, key to preserving sexual function in LUTS treatment, unlike selective blockers' ejaculatory interference.

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