ATI RN
Principles of Pharmacology Quizlet Questions
Question 1 of 5
All of the following administration routes for drugs are NOT affected by first-pass metabolism, EXCEPT
Correct Answer: A
Rationale: First-pass metabolism occurs when drugs are absorbed from the gastrointestinal tract and pass through the liver before reaching the systemic circulation. The oral route is affected by first-pass metabolism as drugs are metabolized in the liver before entering the bloodstream. Sublingual bypasses the liver due to absorption through the oral mucosa. Intravenous administration delivers drugs directly into the bloodstream, avoiding first-pass metabolism. Rectal administration partially bypasses the liver, but some drug metabolism can still occur. Therefore, the correct answer is A (Oral), as it is affected by first-pass metabolism.
Question 2 of 5
Which of the following drugs most likely has the highest oral bioavailability based on the given data?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
Which of the following conditions most likely delayed the oral absorption of acetaminophen in the patient with the excruciating headache?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
What is the main site of distribution for infliximab?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Which of the following was most likely the half-life of the drug (in hours)?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.