All of the following about free drugs (unbound drugs) in plasma are correct EXCEPT:

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Chapter 14 Drugs for the Reproductive System Questions

Question 1 of 5

All of the following about free drugs (unbound drugs) in plasma are correct EXCEPT:

Correct Answer: A

Rationale: The correct answer is A because highly bound drugs (98% bound) do not have clinically significant drug-drug interactions through displacement from binding sites on plasma proteins. This is because only the unbound (free) fraction of a drug is pharmacologically active and available for interactions. Highly bound drugs are bound to proteins and not readily available for interactions. Regarding the other choices: B: Only free drugs can pass through glomerular filtration - Correct, as only unbound drugs can be filtered through the kidneys. C: Only free drugs become available for hepatic metabolism - Correct, as only unbound drugs can undergo metabolism in the liver. D: Only free drugs can distribute to peripheral tissues - Correct, as only unbound drugs can leave the bloodstream and reach peripheral tissues.

Question 2 of 5

When nonpharmacological treatment fails for constipation, which drug would be a first-line treatment for constipation during pregnancy?

Correct Answer: A

Rationale: The correct answer is A: Docusate sodium. It is a stool softener commonly used during pregnancy due to its safety profile. It helps to soften the stool, making it easier to pass without straining, which is important in preventing constipation. B: Magnesium citrate is not recommended during pregnancy due to its potential to cause diarrhea and electrolyte imbalance. C: Castor oil is not recommended during pregnancy as it can induce labor and has potential side effects. D: Mineral oil is not recommended during pregnancy due to its potential to interfere with nutrient absorption and cause aspiration pneumonia if accidentally inhaled.

Question 3 of 5

Which assessment finding is most concerning when examining a client in preterm labor who is receiving magnesium sulfate?

Correct Answer: C

Rationale: The correct answer is C: Loss of patellar reflexes. This is concerning when examining a client in preterm labor receiving magnesium sulfate due to the risk of magnesium toxicity, which can lead to respiratory depression and cardiac arrest. Loss of patellar reflexes indicates excessive magnesium levels affecting neuromuscular function. Options A and B are common side effects of magnesium sulfate administration. Option D, positive clonus, may also be seen with magnesium toxicity but is not as specific or critical as loss of patellar reflexes in this context.

Question 4 of 5

A client is to receive 10 mg nalbuphine by slow intravenous push for pain relief during labor. During which phase of uterine contractions will the nurse plan to administer nalbuphine?

Correct Answer: C

Rationale: The correct answer is C: Between uterine contractions. Administering nalbuphine during contractions can lead to decreased uterine blood flow, potentially compromising fetal oxygenation. Waiting until between contractions allows for optimal fetal oxygenation and minimizes the risk of uterine hyperstimulation. Administering at the end of a contraction or at any time during a contraction may still pose risks to the fetus.

Question 5 of 5

A client has an epidural for pain control during labor. During the assessment, the nurse notes a drop in the client's blood pressure. Which priority nursing intervention would the nurse do?

Correct Answer: B

Rationale: The correct answer is B: Turn her on her left side. Rationale: 1. Turning the client on her left side promotes blood flow to the placenta, increasing perfusion to the fetus. 2. This position helps alleviate hypotension by preventing compression of the vena cava. 3. It is a non-invasive and immediate intervention to address the drop in blood pressure. Summary: A: Administering low-flow oxygen is not the priority in this case as hypotension is likely due to epidural-induced vasodilation, not hypoxia. C: Assessing urinary output is important but not the immediate priority when addressing a drop in blood pressure. D: Monitoring vaginal bleeding is not relevant to the drop in blood pressure related to epidural administration.

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