Alcohol potentiates:

Correct Answer: D

Rationale: The correct answer is D: All of the above. Alcohol potentiates SNS depressants by enhancing their sedative effects, vasodilators by causing further relaxation of blood vessels, and hypoglycemic agents by lowering blood sugar levels. This occurs due to alcohol's ability to enhance the effects of these substances, leading to increased sedation, blood vessel dilation, and blood sugar reduction when combined. Therefore, choosing any of the other options would be incorrect as they do not encompass the full range of substances that alcohol can potentiate.

Correct Answer: A

Rationale: The correct answer is A: Amitriptyline. Amitriptyline is a tricyclic antidepressant that can worsen symptoms in patients with prostatic hypertrophy, glaucoma, coronary, and cerebrovascular disease due to its anticholinergic effects. It can cause urinary retention in prostatic hypertrophy, increase intraocular pressure in glaucoma, and exacerbate cardiovascular conditions. Paroxetine, Bupropion, and Fluoxetine are generally safer options as they have less anticholinergic effects and are less likely to exacerbate these conditions.

Correct Answer: D

Rationale: The correct answer is D, all of the above. Anxiolytic dosage reduction is recommended in patients taking cimetidine due to potential drug interactions. In patients with hepatic dysfunction, reduced metabolism can lead to increased drug levels. Elderly patients may be more sensitive to anxiolytics due to age-related changes in metabolism and increased risk of adverse effects. Therefore, all three factors (cimetidine use, hepatic dysfunction, and age) can influence anxiolytic dosing, making D the correct choice.

Correct Answer: A

Rationale: Rationale: Inhaled anesthetics and intravenous agents with general anesthetic properties directly activate GABAA receptors. GABAA receptors are inhibitory neurotransmitter receptors in the brain. Activation of GABAA receptors leads to hyperpolarization of the neuron, resulting in decreased neuronal excitability and ultimately producing the anesthetic effect. Summary: A: Direct activation of GABAA receptors is correct as it aligns with the mechanism of action of general anesthetics. B: Facilitating GABA action but not directly acting on GABAA receptors is incorrect as direct activation is necessary for the anesthetic effect. C: Reducing glutamatergic neurotransmission is incorrect as it is not the primary mechanism of action for general anesthetics. D: Increasing the duration of opening of nicotine-activated potassium channels is incorrect as it is not related to the mechanism of action of general anesthetics.

Correct Answer: B

Rationale: The correct answer is B: Zafirlucast, a leucotriene receptor antagonist. Leukotrienes are inflammatory mediators in asthma. Zafirlucast specifically blocks the action of leukotrienes by binding to their receptors, reducing inflammation and bronchoconstriction. Sodium cromoglycate (A) is a mast cell stabilizer, not a leukotriene receptor antagonist. Zileutin (C) inhibits 5-lipoxygenase, an enzyme involved in leukotriene synthesis. Triamcinolone (D) is a corticosteroid that acts through a different anti-inflammatory mechanism.