ATI RN
Central Nervous System Stimulants and Related Drugs NCLEX Questions Quizlet Questions
Question 1 of 5
After norepinephrine is released, it binds to receptors on the target organs. Then, it must be removed from the synaptic space. Which of the following mechanisms describes correct removal of norepinephrine from the synaptic space?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
A 58-year-old man with Parkinson's disease presents to the clinic for follow-up. Recently, he has experienced an increase in his resting tremor and rigidity. He was wondering if there is a medication that could help these symptoms. What anticholinergic is the most appropriate treatment?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
A 53-year-old man with schizophrenia presents to his primary care physician for follow-up. He has been treated with multiple different antipsychotic agents during his lifetime. Which of the following antipsychotic agents has the highest affinity for the \(D_2\) receptors?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
Side effects shared by NSAIDs include all the following EXCEPT:
Correct Answer: A
Rationale: NSAIDs, such as ibuprofen, aspirin, and naproxen, share a side effect profile linked to their inhibition of COX enzymes, which reduces protective prostaglandins. Gastrointestinal ulceration occurs due to decreased mucus production in the stomach, increasing risks of bleeding or ulcers, a well-known issue with chronic use. Nephropathy results from reduced renal prostaglandin synthesis, impairing kidney perfusion and potentially leading to acute or chronic renal damage. Hepatotoxicity, though less frequent, can arise from metabolic overload in the liver with prolonged high doses. Addiction, however, is not associated with NSAIDs. It's a characteristic of opioids, which stimulate the brain's reward pathways via mu receptors, fostering dependence. NSAIDs lack psychoactive properties and don't induce euphoria or craving, making Addiction the exception. This question tests the ability to differentiate NSAID toxicities from those of other drug classes, vital for safe prescribing and patient counseling on risks.
Question 5 of 5
Which of the following opioid analgesics induces withdrawal syndrome when given to a morphine addict:
Correct Answer: C
Rationale: Nalbuphine (choice C), a mixed agonist-antagonist (kappa agonist, mu antagonist), can precipitate withdrawal in morphine addicts by antagonizing mu receptors, displacing morphine and reversing its effects, causing symptoms like anxiety and sweating. Meperidine (choice A), Methadone (choice B), and Fentanyl (choice D), all full mu agonists, maintain opioid effects, not inducing withdrawal unless stopped abruptly. Nalbuphine's antagonistic action at mu receptors in dependent patients makes it the correct choice. This highlights the importance of receptor pharmacology in managing opioid-dependent patients, avoiding unintended withdrawal.