After chronic systemic therapy, withdrawal of corticosteroids should be gradual because:

Correct Answer: B

Rationale: The correct answer is B: Abrupt withdrawal may reactivate the underlying disease. When corticosteroids are used chronically, the body's natural production of cortisol is suppressed. Abruptly stopping corticosteroid therapy can lead to adrenal insufficiency and potentially reactivate the underlying disease due to the sudden drop in cortisol levels. Option A is incorrect because corticosteroids do not produce psychological dependence. Option C is incorrect as rebound hypertension is not a typical consequence of corticosteroid withdrawal. Option D is incorrect as only option B is directly related to the physiological consequences of abrupt corticosteroid withdrawal.

Correct Answer: A

Rationale: The correct answer is A. Anabolic steroids are not legitimate for enhancing sports performance due to ethical and health risks. Suboptimal growth in children, senile osteoporosis, and hypoplastic anemia are valid medical uses of anabolic steroids. Sports performance enhancement can lead to unfair competition, health issues, and legal implications.

Correct Answer: C

Rationale: The correct answer is C: Cyproterone acetate. Cyproterone acetate is a potent antiandrogen due to its ability to competitively block androgen receptors. It also exhibits weak progestational activity, making it effective in treating conditions like hirsutism and acne. Ethylestrenol (A) is an anabolic steroid, Clomiphene citrate (B) is a selective estrogen receptor modulator, and Magestrol acetate (D) is a progestin with no antiandrogenic properties.

Correct Answer: D

Rationale: The correct answer is D because finasteride inhibits the enzyme 5-alpha reductase, which is responsible for converting testosterone to dihydrotestosterone (DHT). By lowering circulating as well as prostatic DHT concentration, finasteride effectively reduces the androgenic effect on the prostate, leading to shrinkage of the prostate gland and improvement in symptoms of benign prostatic hyperplasia. A: Blocking testosterone receptors in the prostate gland is incorrect because finasteride does not directly block testosterone receptors. B: Reducing testosterone secretion from testes is incorrect because finasteride does not affect testosterone secretion. C: Reducing LH secretion from pituitary is incorrect because finasteride does not directly influence LH secretion.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.