ATI RN
Musculoskeletal disorder Questions
Question 1 of 5
Adverse effects associated with penicillamine include:
Correct Answer: D
Rationale: Penicillamine causes thrombocytopenia (A), leucopenia (B), glomerulonephritis (C), loss of taste (D), and rarely myasthenia gravis (E), reflecting its broad toxicity profile.
Question 2 of 5
The following are likely to be effective in the treatment of an acute episode of gout:(Select one that does not apply)
Correct Answer: C
Rationale: Indometacin (A) and naproxen (B), NSAIDs, and colchicine (E) are effective for acute gout by reducing inflammation. Alendronate (C, a bisphosphonate) treats osteoporosis, not gout, and probenecid (D) is for chronic management, not acute attacks.
Question 3 of 5
The following may cause hyperuricaemia:(Select one that does not apply)
Correct Answer: A
Rationale: Cytosine arabinoside (B) causes tumor lysis syndrome with hyperuricemia, bendroflumethiazide (C, a thiazide diuretic) reduces urate excretion, and low-dose aspirin (D) inhibits urate secretion. Sulfinpyrazone (A) lowers urate, and bezafibrate (E) has minimal urate effect.
Question 4 of 5
Allopurinol:
Correct Answer: A
Rationale: Allopurinol inhibits xanthine oxidase (A), reducing uric acid, but can precipitate acute gout (B) during initiation due to urate mobilization. It’s not contraindicated in renal failure (C, dose-adjusted), can be used with NSAIDs (D), and doesn’t affect suxamethonium (E).
Question 5 of 5
In a patient with osteoarthritis:
Correct Answer: A
Rationale: Exercise and weight loss (A) reduce joint stress in osteoarthritis. NSAIDs (B) are used for pain, gold therapy (C) is for rheumatoid arthritis not osteoarthritis, bisphosphonates (D) treat osteoporosis not worsening OA, and raloxifene (E) has no proven effect on OA progression.