A48-year-old man had a long history of classic migraine that was recently well controlled by sumatriptan. Which of the following parts of the central nervous system was most likely a primary site of therapeutic action of the drug in the patient's disease?

Correct Answer: B

Rationale: The correct answer is B: Trigeminal nerve. Sumatriptan is a serotonin receptor agonist that acts on serotonin receptors in the trigeminal nerve to reduce inflammation and pain associated with migraines. The trigeminal nerve is a key player in the pathophysiology of migraines, transmitting pain signals from blood vessels and meninges to the brain. The other choices (A: Nucleus accumbens, C: Vestibular nuclei, D: Chemoreceptor trigger zone) are not directly involved in the pathophysiology of migraines or the mechanism of action of sumatriptan. The nucleus accumbens is primarily associated with reward and motivation, the vestibular nuclei are involved in balance and spatial orientation, and the chemoreceptor trigger zone is related to the regulation of vomiting.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.