A subacute toxic effect occurs when the adverse drug effect occurs:

Correct Answer: C

Rationale: The correct answer is C: after repeated exposure for days. Subacute toxic effects typically manifest after a period of time that is longer than immediate (A) or acute (B) effects but shorter than chronic effects (D). This duration of days aligns with the definition of subacute, which refers to effects that occur gradually over a relatively short time frame. It is important to differentiate between the timing of toxic effects to accurately assess the potential harm caused by a substance. Choices A, B, and D are incorrect because they do not align with the characteristic time frame associated with subacute toxic effects.

Correct Answer: C

Rationale: The correct answer is C: Van Leeuwenhoek. Van Leeuwenhoek was a Dutch scientist known for his pioneering work in microscopy. He was the first to observe microbial life, including bacteria on teeth, using his handmade microscopes in the 17th century. Jenner (choice A) is known for developing the smallpox vaccine, not for microbial observations. Semmelweis (choice B) discovered the importance of handwashing in preventing infections. Pasteur (choice D) is famous for his work on pasteurization and germ theory, but not specifically for observing microbial life on teeth. Van Leeuwenhoek's meticulous observations and groundbreaking discoveries make him the correct choice in this context.

Correct Answer: C

Rationale: Rabbit fever, or tularemia, is caused by Francisella tularensis. This bacterium is known to infect a wide range of animals, including rabbits. The other choices, Bartonella henselae (causes cat scratch fever), Spirillum minus (causes rat bite fever), and Yersinia pestis (causes plague) are not associated with rabbit fever. Therefore, the correct answer is C based on the specific pathogen responsible for causing tularemia.

Correct Answer: D

Rationale: The correct answer is D because bacterial vaginitis is often caused by an imbalance in the vaginal flora, which can be disrupted by frequent douching (eliminating beneficial bacteria), tight clothing (restricting airflow), and non-breathable underwear. Avoiding tight pants and using cotton underwear allow for better ventilation, promoting a healthy vaginal environment. Infrequent douching helps maintain the natural balance of bacteria in the vagina. Choices A and B are incorrect because they recommend practices that can disrupt the vaginal flora and increase the risk of bacterial vaginitis. Choice C is partially correct but lacks the emphasis on avoiding frequent douching, which is crucial in preventing bacterial vaginitis.

Correct Answer: D

Rationale: The correct answer is D: polyomavirus infections. Polyomavirus infections do not typically recur during pregnancy because once the virus infects the body, it remains latent without causing recurrent infections. In contrast, choices A, B, and C can recur during pregnancy due to their ability to reactivate from latency or reinfect the host. Epstein-Barr virus infections (choice A) can lead to infectious mononucleosis, herpes simplex virus infections (choice B) can cause recurrent genital or oral herpes outbreaks, and streptococcal infections (choice C) can result in recurrent throat or skin infections.