A primary care physician is treating several patients with hypertension and chronic angina. Which of the following patient subsets would best benefit from treatment with ranolazine?

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: A

Rationale: The correct answer is A: Depression. Decreased TSH levels are associated with hyperthyroidism, which can lead to symptoms like depression due to the impact on neurotransmitters. Fatigue may be seen in hypothyroidism with increased TSH levels. Increased libido is more commonly associated with hyperthyroidism. Mania is not typically linked to thyroid disorders.

Correct Answer: A

Rationale: The correct answer is A because sore throat, fever, and malaise could indicate a serious adverse reaction like infection or agranulocytosis, requiring immediate intervention. B is incorrect as akathisia and hypersalivation are typically related to antipsychotic medications and are not immediate concerns. C, akinesia, and insomnia are not typically acute side effects. D, dry mouth, and urinary retention are common side effects of many medications and are not typically urgent.

Correct Answer: D

Rationale: The correct answer is D: Urinary retention. Imipramine is a tricyclic antidepressant that can cause anticholinergic side effects like urinary retention. This is a serious condition that requires immediate medical attention to prevent complications such as urinary tract infection or bladder damage. Dry mouth (A), blurred vision (B), and nasal congestion (C) are common side effects of imipramine that are usually mild and do not necessitate immediate medical attention.