A patient with diarrhea had stool culture revealing non-lactose-fermenting, Gram-negative rods. The bacteria were oxidase-positive and fermentative. What is the most likely causative agent?

Correct Answer: C

Rationale: The correct answer is C: Salmonella typhi. The patient's symptoms of diarrhea and the characteristics of non-lactose-fermenting, Gram-negative rods that are oxidase-positive and fermentative are consistent with Salmonella typhi. Salmonella typhi is the causative agent of typhoid fever, which presents with symptoms like diarrhea. Pseudomonas aeruginosa (choice A) is oxidase-positive but not fermentative. Escherichia coli (choice B) is both lactose-fermenting and oxidase-negative. Shigella dysenteriae (choice D) is oxidase-negative. Therefore, Salmonella typhi is the most likely causative agent based on the given information.

Correct Answer: A

Rationale: The correct answer is A, Clostridium botulinum. This bacterium produces botulinum toxin, leading to botulism. It is commonly found in soil and improperly canned food. Clostridium tetani causes tetanus, Staphylococcus aureus causes food poisoning, and Salmonella enterica causes salmonellosis. Therefore, A is correct due to its association with botulism, while the other choices are incorrect for causing different diseases.

Correct Answer: D

Rationale: The correct answer is D (All of the above) as all three bacteria (Escherichia coli, Salmonella enterica, Neisseria meningitidis) produce endotoxins causing fever and shock. Endotoxins are lipopolysaccharides found in the outer membrane of Gram-negative bacteria and can trigger an immune response leading to fever and shock. Escherichia coli and Salmonella enterica are common causes of food poisoning and sepsis, while Neisseria meningitidis is responsible for meningococcal meningitis and septicemia. Therefore, all three choices are correct in producing endotoxins that can cause fever and shock.

Correct Answer: B

Rationale: The correct answer is B: Clostridium tetani. Clostridium tetani produces tetanospasmin, a neurotoxin causing tetanus. It enters the body through wounds and affects the nervous system. A: Clostridium botulinum produces botulinum toxin causing botulism, not tetanus. C: Streptococcus pneumoniae causes pneumonia, not tetanus. D: Mycobacterium tuberculosis causes tuberculosis, not tetanus.

Correct Answer: A

Rationale: The correct answer is A: prions. Prions are misfolded proteins that can cause spongiform encephalopathy by inducing normal proteins to misfold as well. Prions lack genetic material, distinguishing them from viruses (B), bacteria (C), and fungi (D), which all contain genetic material and cannot directly cause spongiform encephalopathy through protein misfolding.