A patient with AIDS and a CD4 cell count of 100/Î¼L has persistent fever and weight loss associated with invasive pulmonary disease that is due to M avium complex. Optimal management of this patient is to

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ABVD chemotherapy drugs Questions

Question 1 of 5

A patient with AIDS and a CD4 cell count of 100/Î¼L has persistent fever and weight loss associated with invasive pulmonary disease that is due to M avium complex. Optimal management of this patient is to

A. Treat with rifabutin, since it prevents the development of MAC bacteremia B. Select an antibiotic regimen based on drug susceptibility of the cultured organism C. Start treatment with INH and pyrazinamide D. Treat the patient with clarithromycin, ethambutol, and rifabutin

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 2 of 5

Which one of the following drugs is least likely to be effective in the treatment of esophageal candidiasis, it is used by the oral route?

A. Amphotericin B B. Clotrimazole C. Fluconazole D. Griseofulvin

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 3 of 5

Which one of the following statements about the mechanisms of action of antiviral drugs is least accurate?

A. The initial step in activation of famciclovir in HSV-infected cells is its phosphorylation by viral thymidine kinase B. The reverse transcriptase of HIV is 30-50 times more sensitive to inhibition by indinavir than host cell DNA polymerases C. Gancicolvir inhibits viral DNA polymerase but does not cause chain termination D. Increased activity of host cell phosphodiesterases that degrade tRNA is one of the antiviral actions of interferons

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 4 of 5

Regarding interferon alpha, which one of the following statements is least accurate?

A. At the start of treatment, most patients experience flu-like symptoms B. Indications include treatment of genitalwarts C. It is used in the management of hepatitis C D. Lamivudine interferes with its activity against hepatitis B

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 5 of 5

Which statement regarding phase-specific chemotherapic agents is correct? They

A. Are most effective in one phase of the cell cycle B. Effective in all phases of the cell cycle C. Are only effective in G0 phase D. Include the alkylating agents

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

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