ATI RN
ATI Capstone Pharmacology Assessment 2 Questions
Question 1 of 5
A patient undergoing chemotherapy for breast cancer asks why she is not receiving trastuzumab like her sister. Which response by the nurse is correct?
Correct Answer: D
Rationale: Trastuzumab is a targeted therapy used specifically for HER2-positive breast cancer. If the patient's cancer cells do not overexpress the HER2 receptor, trastuzumab will not be effective. The decision to use targeted therapy is based on the molecular characteristics of the tumor, not the patient's age, insurance coverage, or estrogen receptor status. The nurse should explain that targeted therapies are tailored to the specific biology of the cancer, and trastuzumab is only appropriate for HER2-positive tumors.
Question 2 of 5
Thiopental is used as an anesthetic agent during surgery to repair a small-bowel obstruction in a 78-year-old man. Approximately 1 day after his surgery, toxicology studies still reveal some thiopental present in the bloodstream. What is the most likely explanation for this finding?
Correct Answer: C
Rationale: Thiopental, a barbiturate, persists 24 hours post-surgery. Physiologic metabolism is correct-its lipophilicity causes redistribution to fat, with slow hepatic metabolism, normal in the elderly. Hepatitis or insufficiency lacks evidence. Renal failure doesn't primarily clear it. Trauma (E) is unrelated. This reflects thiopental's pharmacokinetics, not pathology.
Question 3 of 5
A patient undergoing chemotherapy for breast cancer asks why she is not receiving trastuzumab like her sister. Which response by the nurse is correct?
Correct Answer: D
Rationale: Trastuzumab is a targeted therapy used specifically for HER2-positive breast cancer. If the patient's cancer cells do not overexpress the HER2 receptor, trastuzumab will not be effective. The decision to use targeted therapy is based on the molecular characteristics of the tumor, not the patient's age, insurance coverage, or estrogen receptor status. The nurse should explain that targeted therapies are tailored to the specific biology of the cancer, and trastuzumab is only appropriate for HER2-positive tumors.
Question 4 of 5
Upon preparing to administer activated charcoal by mouth to treat a patient who took an overdose of aspirin and several unknown drugs, the nurse notes that the patient has become very somnolent and eyes open only to a noxious stimulus. Which action by the nurse is most appropriate at this point?
Correct Answer: A
Rationale: The patient's decreased level of consciousness (somnolence and only responding to noxious stimuli) indicates a potential deterioration in their condition, possibly due to the overdose. Activated charcoal is contraindicated in patients with an altered mental status due to the risk of aspiration. The nurse should immediately consult the nurse practitioner to reassess the patient's condition and determine the appropriate intervention, such as securing the airway or considering alternative treatments.
Question 5 of 5
Which of the following describes the action of an agonist on a receptor.
Correct Answer: C
Rationale: An agonist is a substance that binds to a receptor and triggers a biological response. By activating the receptor, an agonist mimics the action of the body's natural ligand that typically binds to the receptor. This activation may lead to a cascade of events within the cell, resulting in a specific physiological response. In contrast, antagonists block the receptor from being activated, while agonists work by binding to the receptor and initiating the desired response.