A patient suffering form tuberculosis was treated with rifampicin, which caused drug resistance of tuberculosis mycobacteria. In order to reduce mycobacteria resistance, rifampicin should be combined with the following drug:

Correct Answer: A

Rationale: The correct answer is A: Isoniazid. When rifampicin is used alone, there is a risk of developing resistance. Isoniazid is commonly used in combination with rifampicin to prevent resistance by targeting different mechanisms in the bacteria. Isoniazid works by inhibiting mycolic acid synthesis, while rifampicin targets RNA polymerase. This combination therapy is known as the first-line treatment for tuberculosis. Choices B, C, and D are incorrect because they do not have the same mechanism of action as isoniazid and would not be effective in preventing rifampicin resistance.

Correct Answer: A

Rationale: The correct answer is A: Leptospira. Leptospira is a spiral-shaped bacterium that causes a disease known as leptospirosis, characterized by fever, jajsondice, hemorrhagic rash, and renal insufficiency. The characteristic spiral shape of the bacteria, resembling 'C' and 'S' letters, is a key identifying feature. Leptospira is commonly associated with contaminated water sources and can be transmitted to humans through contact with infected animals or water. Summary of other choices: B: Treponema - Treponema pallidum is the causative agent of syphilis, which does not typically present with the combination of symptoms described in the question. C: Borrelia - Borrelia species are associated with Lyme disease and relapsing fever, but do not match the specific symptoms and histological appearance described in the question. D: Spirochaeta - Spirochaeta is a genus of bacteria, but specific species within

Correct Answer: C

Rationale: The correct answer is C: Corynebacterium diphtheriae. This bacterium causes diphtheria, a disease characterized by a pseudomembrane in the throat. This pseudomembrane is a result of the bacterial exotoxins causing inflammation and necrosis of the throat tissues. Clostridium tetani (A) causes tetanus, characterized by muscle stiffness, not a pseudomembrane in the throat. Bordetella pertussis (B) causes whooping cough, with symptoms of severe coughing fits but no pseudomembrane. Streptococcus pyogenes (D) causes strep throat, but does not produce a pseudomembrane.

Correct Answer: C

Rationale: The correct answer is C: Gram-positive rod-shaped bacteria. Listeria monocytogenes is a Gram-positive bacterium, as it retains the crystal violet stain during the Gram staining process. The bacteria are rod-shaped, not spherical. Choice A is incorrect as Listeria monocytogenes is not Gram-negative. Choice D is incorrect as Listeria monocytogenes does fall under the category of Gram-positive bacteria. The key is to remember the characteristics of Listeria monocytogenes, which are Gram-positive and rod-shaped.

Correct Answer: B

Rationale: The correct answer is B: Orthomyxovirus type 1. Family Reoviridae includes Orthoreovirus types 1, 2, and 3. Orthomyxovirus belongs to a different family, Orthomyxoviridae. Therefore, B is the correct answer. Orthoreovirus types 1, 2, and 3 are part of the Reoviridae family. Choice A, C, and D are incorrect because they are all part of the Reoviridae family which includes Orthoreoviruses.

Correct Answer: A

Rationale: The correct answer is A: Itraconazole. Itraconazole is an antifungal medication commonly used to treat candidosis. It works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This action disrupts the integrity of the fungal cell membrane, leading to cell death. Griseofulvin (B) is primarily used to treat fungal infections of the skin and nails, not mucous membranes. Nitrofungin (C) is not commonly used for candidosis treatment. Amphotericin (D) is a potent antifungal medication but is typically reserved for severe or systemic fungal infections due to its potential side effects.

Correct Answer: C

Rationale: The correct answer is C: IgA. IgA is the most prominent immunoglobulin class present in external secretions like saliva, tears, and mucus. It plays a crucial role in mucosal immunity by preventing pathogens from entering the body. IgG is mainly found in the blood and tissues, IgM is the first antibody produced in response to an infection, and IgE is involved in allergic reactions. IgA's presence in external secretions helps protect the body from infections at mucosal surfaces, making it the correct choice in this context.

Correct Answer: A

Rationale: The correct answer is A: Clostridium botulinum. This bacterium is associated with food poisoning from improperly canned foods due to its ability to produce botulinum toxin, a potent neurotoxin that causes botulism. Improper canning allows spores of Clostridium botulinum to survive and germinate, producing the toxin in anaerobic conditions. The other choices are incorrect because Escherichia coli, Salmonella enterica, and Vibrio cholerae are not typically associated with food poisoning from improperly canned foods. Escherichia coli and Salmonella are more commonly linked to contaminated water or undercooked food, while Vibrio cholerae causes cholera primarily through contaminated water sources.

Correct Answer: B

Rationale: The correct answer is B: Thayer-Martin agar. This selective media contains antibiotics that inhibit the growth of other organisms while allowing Neisseria gonorrhoeae to grow. The antibiotics in Thayer-Martin agar include vancomycin, colistin, nystatin, and trimethoprim, which target different types of bacteria, ensuring the isolation of N. gonorrhoeae. Phenylethyl alcohol agar (A) is used to isolate gram-positive organisms, not N. gonorrhoeae. MacConkey agar (C) is selective for gram-negative enteric bacteria. Mannitol salt agar (D) is used for isolating Staphylococcus species based on their ability to ferment mannitol.