A patient returning from Congo republic a week ago is with fever, headache vomiting and diarrhea, Three days after his admission to the infectious ward, despite antibiotic therapy, severe hemorrhagic syndrome developed and as well as CNS involvement, The diagnosis is hemorrhagic fever. Which of these viruses can be a causative agent?

Correct Answer: C

Rationale: The correct answer is C: Ebola virus. The patient's symptoms align with Ebola virus infection, including fever, severe hemorrhagic syndrome, and CNS involvement. Ebola virus is known to cause hemorrhagic fevers with high mortality rates. A: SARS CoV causes Severe Acute Respiratory Syndrome, which typically presents with respiratory symptoms, not hemorrhagic fever. B: Lymphocytic choriomeningitis virus usually causes a mild illness with flu-like symptoms, not severe hemorrhagic syndrome. D: ECHO 9 virus is associated with aseptic meningitis, not hemorrhagic fever.

Correct Answer: A

Rationale: The correct answer is A because it accurately describes the major morphological forms of bacteria. Cocci are spherical, rod-shaped bacteria are called bacilli, and curved bacteria are spirilla. Staphylococci, streptococci, and diplococci are specific types of cocci, not major morphological forms. Basicili and spiralis are not common morphological forms of bacteria. Option D is incorrect as the other choices do represent major morphological forms of bacteria.

Correct Answer: B

Rationale: The correct answer is B: Hepatitis B virus. This is because Hepatitis B virus is a DNA virus, not an RNA virus. The other choices, A (Hepatitis G virus), C (Hepatitis A virus), and D (Hepatitis E virus) are all RNA viruses. Hepatitis B virus is unique as it contains partially double-stranded DNA. DNA viruses replicate through a DNA intermediate, unlike RNA viruses which directly use RNA. Therefore, Hepatitis B virus stands out as the only DNA virus among the given options.

Correct Answer: B

Rationale: The correct answer is B: Zoonosis. Tularemia is primarily a zoonotic disease, meaning it is transmitted from animals to humans. The bacterium that causes tularemia, Francisella tularensis, commonly infects animals like rabbits, rodents, and ticks, which serve as reservoir hosts. Humans can get infected through direct contact with infected animals, insect bites, or contaminated water or soil. This zoonotic nature of tularemia distinguishes it from anthroponosis (A), which is transmitted only between humans, and sapronosis (C), which is transmitted through non-living environmental sources. Choice D is incorrect because there is a correct answer, which is zoonosis.

Correct Answer: A

Rationale: The correct answer is A: Doxycycline. It is a broad-spectrum antibiotic effective against a wide range of bacteria, including those causing infections like Lyme disease and pneumonia. Doxycycline is often the first-line treatment for these infections due to its efficacy and low risk of resistance. Chloramphenicol (B) has serious side effects and is reserved for specific cases. Penicillin (C) is not effective against all bacteria and may not cover the specific infection. Streptomycin (D) is mainly used for certain types of bacterial infections and is not the optimal choice for the conditions mentioned in the question.

Correct Answer: A

Rationale: The correct answer is A: Yersinia pestis. Y. pestis is a Gram-negative rod that exhibits a 'safety pin' appearance on staining due to bipolar staining. This bacterium is the causative agent of plague, which can present as painful ulcers known as buboes. Y. pestis is transmitted by fleas and can cause outbreaks in humans. Summary: - B: Francisella tularensis causes tularemia, not typically associated with painful ulcers. - C: Brucella abortus causes brucellosis, which does not typically present with painful ulcers. - D: Clostridium botulinum causes botulism, characterized by muscle weakness and paralysis, not painful ulcers.

Correct Answer: A

Rationale: The correct answer is A because significant bacteriuria is defined as having more than 10^5 cells in 1 ml of midstream morning urine. This concentration indicates a true infection rather than contamination. Choice B is incorrect because the amount of urine does not determine significant bacteriuria. Choice C is incorrect because even a single bacterium in urine does not necessarily indicate an infection. Choice D is incorrect because not all statements are correct; only choice A accurately defines significant bacteriuria based on the bacterial concentration in urine samples.

Correct Answer: D

Rationale: The correct answer is D because utilizing all three methods—immunofluorescence, viral neutralization reaction, and electron microscopy—provides a comprehensive and rapid diagnosis of various viral infections. Immunofluorescence detects viral antigens directly, viral neutralization reaction demonstrates the presence of specific antibodies, and electron microscopy visualizes viral particles. This combination ensures accurate and quick identification of different viruses. Choices A, B, and C alone may not cover all aspects of viral diagnosis, making them less effective compared to the comprehensive approach of using all three methods.

Correct Answer: B

Rationale: The correct answer is B, Antony van Leeuwenhoek. He was the first to observe and describe "animalcules" (microorganisms) through his early microscopes. Robert Hooke (A) is known for his work with cells but did not discover animalcules. Hans Janssen (C) and John Needham (D) did not make significant contributions to the discovery of microorganisms. Leeuwenhoek's pioneering observations were crucial in the development of microbiology.