ATI RN
ATI Pharmacology Made Easy 4.0 Infection Questions
Question 1 of 5
A patient receiving a targeted therapy asks the nurse why St. John's wort must be avoided. Which response by the nurse is most appropriate?
Correct Answer: B
Rationale: St. John's wort induces the activity of cytochrome P450 enzymes, which metabolize many targeted therapies. This can lead to decreased blood levels of the targeted therapy, reducing its effectiveness. Patients should be advised to avoid St. John's wort to ensure optimal therapeutic outcomes. The other options are incorrect because St. John's wort does not increase blood levels of targeted therapies, cause overdose, or bind with drugs in the intestinal tract.
Question 2 of 5
While caring for a patient with cirrhosis or hepatitis, the nurse knows that abnormalities in which phase of pharmacokinetics may occur?
Correct Answer: C
Rationale: Cirrhosis and hepatitis impair liver function, which directly affects the metabolism of drugs. The liver is responsible for metabolizing many medications through processes such as oxidation, reduction, and hydrolysis. When liver function is compromised, drug metabolism may be slowed, leading to increased drug levels and a higher risk of toxicity. While absorption, distribution, and excretion can also be affected by liver disease, metabolism is the most significantly impacted phase. Therefore, nurses must carefully monitor drug dosages and consider alternative medications for patients with liver dysfunction.
Question 3 of 5
Jonas comes into the local blood donation center. He says he is here to donate platelets only today. The nurse knows this process is called:
Correct Answer: C
Rationale: Apheresis is the process of selectively collecting specific blood components, such as platelets, while returning the remaining components to the donor. This method allows for the efficient collection of platelets without depleting the donor's red blood cells or plasma. Directed donation refers to donating blood for a specific recipient, autologous donation involves donating one's own blood for future use, and allogeneic donation is the standard donation for the general blood supply. Therefore, apheresis is the correct term for platelet-only donation.
Question 4 of 5
A 20-year-old man is diagnosed to have acute schizophrenia. Which of the following is an appropriate first-line treatment?
Correct Answer: C
Rationale: Acute schizophrenia requires antipsychotics for positive symptoms (e.g., hallucinations). IV haloperidol is for acute agitation, not first-line outpatient treatment. IM flupentixol, a long-acting typical antipsychotic, suits maintenance, not initial therapy. Oral olanzapine, an atypical antipsychotic, is first-line, balancing efficacy (D2/5-HT2 blockade) and lower extrapyramidal risk, suitable for a young patient. Procyclidine treats parkinsonism, not schizophrenia. Fluoxetine is for depression. Olanzapine's oral route and profile make it ideal for initial management, promoting adherence and tolerability.
Question 5 of 5
All are true about penicillins EXCEPT:
Correct Answer: B
Rationale: Penicillins cross the blood-brain barrier mainly when meninges are inflamed (e.g., meningitis), a true statement due to increased permeability. They do require dose adjustment in renal failure, as they're renally excreted, making the lack of adjustment false and the exception. They inhibit bacterial cell wall synthesis by blocking peptidoglycan cross-linkage, a true mechanism. Piperacillin is effective against Pseudomonas, especially with tazobactam, which is true. Only 5-10% of those with prior penicillin allergy react again, also true. The renal adjustment need is critical, as accumulation risks toxicity like seizures, guiding safe prescribing in kidney dysfunction.