A patient is presented with weakness of legs, arms, trunk, tingling and numbness that progressively worsens. Peripheral blood smear shows macrocytic anemia. Which of the following is not the factor causing this condition?

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Question 1 of 5

A patient is presented with weakness of legs, arms, trunk, tingling and numbness that progressively worsens. Peripheral blood smear shows macrocytic anemia. Which of the following is not the factor causing this condition?

Correct Answer: C

Rationale: The correct answer is C: Tapeworm infestation. The symptoms described suggest vitamin B12 deficiency, which can lead to macrocytic anemia. Chronic atrophic gastritis can cause decreased intrinsic factor production, leading to impaired B12 absorption. Ileal resection can also affect B12 absorption as it is the site where B12 is absorbed. Alcoholism can lead to poor dietary intake and impaired B12 absorption. However, tapeworm infestation does not directly affect B12 absorption and would not be a likely cause of the described symptoms.

Question 2 of 5

A patient is presented with fever, vomiting, hypotension and facial edema after his business trip back from Africa. Viral hemorrhagic fever is suspected in this patient. Which of the following family does the suspected virus belong to?

Correct Answer: A

Rationale: The correct answer is A: Filovirus. Filoviruses, such as Ebola and Marburg viruses, are known to cause viral hemorrhagic fevers and are commonly found in Africa. The symptoms presented by the patient align with those of filovirus infections. Togavirus (choice B) and Bunyavirus (choice D) are not typically associated with viral hemorrhagic fevers. Adenovirus (choice C) can cause respiratory and gastrointestinal infections but is not known to cause viral hemorrhagic fevers.

Question 3 of 5

After seven days of treatment with sulfonamides, a patient's hemoglobin had decreased from 14.7 gm/100ml to 10gm/100ml. The most likely cause of hemolysis in this patient is

Correct Answer: D

Rationale: The correct answer is D: Glucose 6-phosphate dehydrogenase deficiency (G6PD). G6PD deficiency can cause hemolysis in response to oxidative stress, such as medications like sulfonamides. The decrease in hemoglobin levels after sulfonamide treatment indicates hemolysis, which is a common manifestation of G6PD deficiency. Sickle cell disease (A), thalassemia minor (B), and hereditary spherocytosis (C) do not typically present with hemolysis triggered by sulfonamides. G6PD deficiency is the most likely cause in this scenario due to the timing of hemolysis after the drug exposure and the characteristic response of G6PD-deficient red blood cells to oxidative stress.

Question 4 of 5

A 36-year-old woman presented with weakness, lassitude, and feeling easily tired. Her bone marrow aspirate showed 15% myeloblasts and reduced erythropoiesis. The most likely cause is

Correct Answer: D

Rationale: The correct answer is D: Myelodysplastic syndrome. Given the patient's age, symptoms, and bone marrow findings of myeloblasts with reduced erythropoiesis, it aligns with the characteristics of myelodysplastic syndrome. This condition involves abnormal blood cell production leading to cytopenias and an increased risk of progression to acute myeloid leukemia. Acute myeloid leukemia (Choice A) typically presents with higher blast percentages and more aggressive symptoms. Acute lymphoid leukemia (Choice B) is less likely due to the presence of myeloblasts in the bone marrow. Myelofibrosis (Choice C) is characterized by fibrosis in the bone marrow, which is not indicated in this case.

Question 5 of 5

The following pathological features is true regarding non-Hodgkin lymphoma (NHL)

Correct Answer: B

Rationale: The correct answer is B because B cell phenotype is more common in non-Hodgkin lymphoma (NHL). This is supported by the fact that the majority of NHL cases arise from B cells in the lymphoid tissue. Choice A is incorrect as RS cells are characteristic of Hodgkin lymphoma, not NHL. Choice C is incorrect because NHL can involve non-contiguous lymph nodes. Choice D is incorrect because NHL can have a leukemic phase known as leukemic lymphoma.

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