A patient complained about a carbuncle on his face. Examination results: neither dense nor painful edema of subcutaneous cellular tissue, there is black crust in the middle of the carbuncle and peripheral vesicular rash around it. Bacteriological examination revealed presence of immobile streptobacilli able of capsulation. What microorganisms are causative agents of this disease?

Correct Answer: C

Rationale: The correct answer is C: Bacillus anthracoides. 1. The patient's symptoms align with cutaneous anthrax, caused by Bacillus anthracis. 2. Presence of immobile streptobacilli able of capsulation matches the characteristics of Bacillus anthracis. 3. Symptoms such as black crust, peripheral vesicular rash, and non-painful edema are classic for cutaneous anthrax. 4. Choice A: Bacillus antracis is a misspelling, not a valid option. 5. Choice B: Staphylococcus aureus does not match the symptoms described in the scenario. 6. Choice D: Bacillus megaterium is not associated with cutaneous anthrax.

Correct Answer: B

Rationale: B cells develop in the bone marrow, not the thymus. Firstly, hematopoietic stem cells in the bone marrow give rise to B cells. They undergo maturation and selection processes in the bone marrow, not in the thymus. Therefore, choice B is false. On the other hand, choices A, C, and D are correct. A is true because B cells with high affinity to self-antigens undergo apoptosis to prevent autoimmunity. C is true since B cells synthesize antibodies which can be displayed on their surface as B cell receptors. D is true because B cells can undergo class switching to produce different types of antibodies based on the immune response requirements.

Correct Answer: C

Rationale: The correct hierarchical order for virus classification is order, family, subfamily, genus, species. This is because classification starts at a broader level (order) and narrows down to a more specific level (species). Order comes first to group viruses based on common characteristics, followed by family, which further categorizes them. Subfamily refines the classification, then genus groups similar viruses together, and species distinguishes different strains within a genus. Choice A is incorrect because it places genus before family, which is not the correct sequence. Choice B is incorrect as it starts with species, which is the most specific level. Choice D is incorrect because it places genus at the beginning, which is too specific for the hierarchical order.

Correct Answer: A

Rationale: The correct answer is A: Homemade canned meat. Botulism is often caused by consuming improperly canned or preserved foods, particularly meats. The spores of the Clostridium botulinum bacteria can grow in anaerobic conditions, such as those found in improperly canned foods, leading to the production of the botulinum toxin. The symptoms of botulism align with those characteristic of the patient's condition. Explanation of why the other choices are incorrect: B: Custard pastry from private bakery - Unlikely to be the cause of botulism as this type of food is not typically associated with the growth of Clostridium botulinum. C: Sour cream from local dairy factory - While dairy products can sometimes be sources of foodborne illness, botulism is not commonly associated with sour cream. D: Strawberries from suburban vegetable garden - Botulism is not typically transmitted through fresh fruits or vegetables, making this an unlikely source of infection.

Correct Answer: A

Rationale: Ribosomes are responsible for protein synthesis, where they translate the genetic information from mRNA into specific amino acid sequences to form proteins. This process occurs in both prokaryotic and eukaryotic cells. Ribosomes do not participate in the breakdown of substances, which is mainly carried out by lysosomes or proteasomes. Oxidative phosphorylation involves the generation of ATP in mitochondria, not ribosomes. Ribosomes do not inactivate antibiotics; this is typically done by enzymes or chemical modifications. Therefore, the correct answer is A as ribosomes play a crucial role in protein synthesis.

Correct Answer: A

Rationale: The correct answer is A: Clostridium perfringens. Clostridium perfringens is a gram-positive spore-forming bacillus commonly found in soil. It produces hemolysis on blood agar, as described in the question. Clostridium botulinum is also a gram-positive spore-forming bacillus, but it does not typically cause hemolysis. Staphylococcus aureus is a gram-positive cocci, not a bacillus. Pseudomonas aeruginosa is a gram-negative bacterium, not a gram-positive spore-forming bacillus.

Correct Answer: A

Rationale: The correct answer is A: Kitt-Tarozzi. This medium contains blood and hemin, which are essential nutrients for the growth of anaerobes. Blood provides a source of iron, while hemin stimulates the growth of anaerobes. This combination creates an environment conducive for the isolation and identification of anaerobic organisms. B: Endo and C: Roux are selective media primarily used for the isolation of gram-negative bacteria and not specifically designed for anaerobes. D: Sabouraud's is a medium used for the cultivation of fungi, not anaerobes. In summary, Kitt-Tarozzi is the correct choice due to its specific nutrient composition that supports the growth of anaerobes, unlike the other options which are not suitable for this purpose.

Correct Answer: D

Rationale: The correct answer is D because the catarrhal stage of whooping cough is characterized by mild respiratory symptoms such as mild coughing, sneezing, or a runny nose. During this stage, the cough may start to worsen but is not yet severe. A: Incorrect - Decrease in paroxysms of coughing is not seen in the catarrhal stage; it occurs later in the paroxysmal stage. B: Incorrect - Subsequent respiratory infection for many months after the onset of pertussis is not a characteristic of the catarrhal stage. C: Incorrect - Uncontrollable coughing followed by a high pitched 'whoop' sound is typical of the paroxysmal stage, not the catarrhal stage.

Correct Answer: A

Rationale: The correct answer is A: Viruses. Viruses are acellular, meaning they lack cellular structure, protein synthesizing ability, enzymes, and energy systems. They are essentially genetic material (DNA or RNA) enclosed in a protein coat. Fungi (B), bacteria (C), and protozoa (D) are all cellular organisms with protein synthesizing, enzyme, and energy systems. Viruses rely on host cells to replicate and carry out metabolic functions, making them distinct from other groups.