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Basic Principles of Pharmacology Quizlet Questions
Question 1 of 5
A new drug was tested in an in vitro system. It was found that only one enantiomer of the racemic pair bound substantially to a specific receptor, whereas the other enantiomer showed negligible binding. Which of the following terms best defines this property?
Correct Answer: A
Rationale: Stereoselectivity refers to the phenomenon where one enantiomer of a racemic pair exhibits a significantly different interaction compared to the other enantiomer. In this case, the enantiomer that binds substantially to the receptor while the other does not demonstrates stereoselectivity. The term "intrinsic activity" refers to the ability of a drug to activate a receptor, "affinity" refers to the strength of binding between a drug and its receptor, and "potency" refers to the concentration of a drug required to produce a specific effect. Therefore, the correct answer is A.
Question 2 of 5
Consumer safety became an important issue during the latter part of the twentieth century because of the
Correct Answer: D
Rationale: a and c' is correct because consumer safety rose in prominence due to increased drug use (a) and more over-the-counter (OTC) medications (c), heightening risks of misuse and adverse effects. 'b' (therapeutic properties) is a constant concern, not unique to the late twentieth century. Choosing 'a' or 'c' alone ignores the combined impact, and 'all of the above' overstates 'b's specificity. Late twentieth-century trends, like OTC expansion and drug culture shifts, drove safety focus, per historical pharmacology context.
Question 3 of 5
The concentration of active ingredients in a drug preparation
Correct Answer: A
Rationale: Potency' is correct because it defines the concentration or strength of active ingredients needed for a therapeutic effect. 'Quality' is about overall standards, not concentration specifically. 'Efficacy' is the ability to produce results, not ingredient level. 'Purity' is absence of contaminants, not concentration. Potency directly relates to dosage and effect strength, a key pharmacology concept distinguishing it from the others.
Question 4 of 5
A drug with moderate potential for abuse but may have a prescription phoned to the pharmacist with five refills in 6 months
Correct Answer: C
Rationale: Schedule III' is correct because these drugs (e.g., anabolic steroids) have moderate abuse potential, accepted medical use, and allow phoned prescriptions with up to five refills in six months under DEA rules. 'Schedule I' has no use. 'Schedule II' requires written prescriptions. 'Schedule IV' has lower risk but similar refill rules. Schedule III balances risk and flexibility, per pharmacology scheduling.
Question 5 of 5
All drugs with the potential for abuse, as found under the auspices of the Controlled Substances Act of 1970, are followed by the DEA from manufacture to sale in a pharmacy or use by the physician.
Correct Answer: A
Rationale: True' is correct because the DEA tracks controlled substances (Schedules I-V) from manufacture to sale or use under the 1970 Act to prevent diversion. 'False' overlooks this enforcement role. 'Not applicable' pads C/D. The DEA's oversight, distinct from FDA regulation, ensures compliance across the supply chain, per pharmacology law.