ATI RN
Chemotherapy drugs Questions
Question 1 of 5
A missionary from Chicago is sent to work in a geographic region of a Cental American country wher onchocerca volvulus is endemic. Infections due to this tissue nematode (onchocerciasis) are a major cause of 'river blindness', since microfilariae migrate through subcutaneous tissues and concentrate in the eyes. Which one of the following durgs can be used prophylactically to prevent onchocerciasis?
Correct Answer: B
Rationale: Ivermectin is used prophylactically and therapeutically for onchocerciasis by killing microfilariae, preventing 'river blindness'.
Question 2 of 5
Which cell involved in immune function recognizes foreign peptides bound of MHC class II molecules on the surface of APC cells, secretes interleukin-2, and initiates the cell-mediated immunity reaction responsible for host-versus-graft reactions?
Correct Answer: D
Rationale: T-helper (TH) lymphocytes recognize MHC class II-bound peptides, secrete IL-2, and initiate cell-mediated immunity, including host-versus-graft reactions.
Question 3 of 5
Body Surface Area (BSA) is used in calculating chemotherapy doses because
Correct Answer: B
Rationale: BSA correlates with cardiac output and thus drug clearance, providing a standardized way to dose chemotherapy.
Question 4 of 5
Which one of the following agents is able to suppress both B and T lymphocytes via its inhibition of de novo synthesis of purines?
Correct Answer: C
Rationale: Mycophenolate mofetil inhibits inosine monophosphate dehydrogenase, blocking de novo purine synthesis and suppressing both B and T lymphocytes.
Question 5 of 5
In the treatment of acute inorganic arsenic poisoning, the most likely drug to be used is
Correct Answer: B
Rationale: Dimercaprol (BAL) is the drug of choice for acute arsenic poisoning as it chelates arsenic, promoting its excretion.