Correct Answer: A

Rationale: The correct answer is A because several studies have indeed shown an association between BRCA-2 mutation and an increased risk of prostate cancer. BRCA-2 mutation is known to be linked to an increased risk of various cancers, including prostate cancer. This genetic mutation can be inherited and passed down through generations, leading to a higher likelihood of developing prostate cancer. Choices B, C, and D are incorrect because: B: HNPCC (Hereditary Nonpolyposis Colorectal Cancer) is not specifically associated with prostate cancer, and it is not an autosomal dominant mutation causing prostate cancer in men. C: TP53 gene is associated with other types of cancers, such as breast cancer, but not strongly linked to prostate cancer. D: Research has shown that genetics do play a role in the development of prostate cancer, contradicting the statement that genetics are unrelated to the disease.

Correct Answer: C

Rationale: The correct answer is C: Degree of glycemic control before and during the pregnancy. Proper glycemic control is crucial in managing complications in a pregnant patient with diabetes. Uncontrolled blood sugar levels can lead to maternal, fetal, and neonatal complications. Monitoring and maintaining stable blood glucose levels before and during pregnancy help reduce the risk of adverse outcomes. A: Evaluation of retinopathy by an ophthalmologist - Although important for overall health, retinopathy does not directly impact maternal, fetal, and neonatal complications in diabetes during pregnancy. B: The patient’s stable emotional and psychological status - While emotional and psychological well-being are important, they do not directly affect complications related to diabetes in pregnancy. D: Total protein excretion and creatinine clearance within normal limits - While these are indicators of kidney function, they are not the most crucial factors in managing complications in a pregnant patient with diabetes.

Correct Answer: B

Rationale: The correct answer is B: Cholesteatoma. A red blemish behind the tympanic membrane is indicative of a cholesteatoma, which is a noncancerous cyst in the middle ear. This occurs due to the accumulation of skin cells and debris in the middle ear space. Other choices (A, C, D) are not associated with a red blemish on otoscopy. An acoustic tumor (A) typically presents as a slow-growing mass on the vestibulocochlear nerve. Facial nerve neuroma (C) involves the facial nerve and does not typically cause a red blemish. Glomus tympanicum (D) is a vascular tumor arising from the middle ear but does not usually present as a red blemish.

Correct Answer: C

Rationale: The correct answer is C: Meaningful living during terminal illness is best supported in the home. This is because hospice care focuses on providing compassionate care and support in the comfort of the patient's own home, which can enhance quality of life and dignity. Being in a familiar and comfortable environment allows the patient to receive personalized care and emotional support from family members. Options A, B, and D are incorrect because hospice care emphasizes comfort and quality of life over technologic interventions, designated facilities, and prolonging physiologic dying. Ultimately, the goal of hospice care is to prioritize the patient's emotional and physical well-being during the end stages of life.

Correct Answer: D

Rationale: The correct answer is D: Discuss a referral for hospice care. Hospice care provides specialized care for patients with terminal illnesses, focusing on comfort and quality of life. This option aligns with the patient's wish to die at home and ensures his care needs are met. Hospice care also provides emotional and spiritual support for both the patient and family. A: Discuss a referral for rehabilitation hospital - This option focuses on rehabilitation, which is not suitable for a patient with a terminal illness like extensive stage small-cell lung cancer. B: Panel the patient for a personal care home - Personal care homes may not provide the level of specialized care needed for a terminally ill patient. C: Discuss a referral for acute care - Acute care is more focused on treating acute illnesses and injuries, not providing end-of-life care for a patient with a terminal illness.