A male patient with blood type AB, Rh factor positive needs a blood transfusion. The Transfusion Service (blood bank) sends type O, Rh factor negative blood to the unit for the nurse to infuse into this patient. The nurse knows that:

Correct Answer: A

Rationale: In this case, the blood type of the donor (type O, Rh-negative) is not compatible with the blood type of the patient (type AB, Rh-positive). Blood type AB individuals can receive blood from all blood types (universal recipient), but they can only donate to individuals with the same blood type. Therefore, if a patient with blood type AB receives a transfusion of type O blood, it will lead to a major incompatibility reaction, possibly resulting in serious complications such as hemolysis (destruction of red blood cells), renal failure, and even death. It is crucial for the nurse to verify the blood type of the patient and ensure that the correct blood type is provided to prevent such adverse reactions.

Correct Answer: B

Rationale: The presence of small crystals in the IV tubing indicates that the mannitol solution is not suitable for administration due to the risk of causing adverse effects to the patient. Discarding the solution and obtaining a new bag of medication is the most appropriate action to ensure the safety and effectiveness of the infusion. Infusing a solution with crystals can lead to complications such as embolism or tissue damage. It is important to always verify the integrity and clarity of IV solutions before administration to prevent potential harm to the patient.

Correct Answer: A

Rationale: Testosterone patches require placement on hair-free skin to ensure proper adhesion and absorption, as hair can block drug delivery, reducing efficacy. Active areas like the thigh or arm are suitable if hairless and dry, contrary to avoidance claims-rotation across such sites is standard. Patches are changed daily, not weekly, for consistent hormone levels. Rash observation is key due to potential skin irritation, a common side effect. Hair-free placement is critical education, directly impacting bioavailability, unlike timing or site activity, which follow secondary guidelines, ensuring effective therapy for hypogonadism or related conditions.

Correct Answer: C

Rationale: Naloxone is a medication used to treat opioid overdose by rapidly reversing the effects of opioids on the central nervous system. It works by binding to the same receptors in the brain that opioids target, effectively displacing the opioids and reversing their effects. Naloxone can quickly restore normal breathing in individuals who have overdosed on opioids, potentially saving their lives. It is commonly administered in emergency situations, such as in hospitals, ambulances, and by first responders. Naloxone is an essential tool in treating opioid overdose and is considered a life-saving medication in such cases.

Correct Answer: D

Rationale: Antiepileptics vary in side effects. Valproate causes tremor or hepatotoxicity, not visual defects. Carbamazepine risks rash or hyponatremia, not eyes. Lamotrigine is linked to rash, tiagabine to dizziness, without visual impact. Vigabatrin, a GABA-transaminase inhibitor, causes irreversible concentric visual field defects in ~30-40% of users due to retinal toxicity, a unique and serious adverse effect. This necessitates ophthalmologic monitoring, distinguishing it in epilepsy treatment choices.

Correct Answer: A

Rationale: Albuterol is a medication commonly used to treat asthma and other respiratory conditions. It works by relaxing the muscles in the airways, allowing the air passages to widen and making it easier to breathe. This bronchodilation effect helps to relieve symptoms such as wheezing, shortness of breath, and chest tightness. Albuterol is classified as a short-acting beta-agonist, and its therapeutic use lies in its ability to provide quick relief during acute asthma attacks or to prevent exercise-induced bronchospasm.

Correct Answer: A

Rationale: Most beta-blockers (e.g., propranolol, metoprolol) have half-lives of 3-10 hours, a true statement reflecting their typical duration, useful for dosing frequency. They have a large, not small, volume of distribution due to tissue penetration, so that's false. Many have good oral bioavailability, not poor, especially non-selective ones. Lipid solubility varies (e.g., propranolol is high, atenolol low), but many cross the BBB, causing CNS effects, though not universally true. They're often metabolized, not excreted unchanged. The half-life range is a key pharmacokinetic feature, guiding their use in hypertension or angina.

Correct Answer: A

Rationale: Antihistamines target H1 receptors for allergy relief, not B1/B2 (choices B, C) or nonexistent C1 . A reflects their mechanism, making it correct.

Correct Answer: C

Rationale: Acetaminophen overdose with liver failure (elevated AST/ALT) needs N-acetylcysteine , restoring glutathione to detoxify NAPQI. Ammonium chloride and flumazenil are irrelevant. Naloxone treats opioids. Sodium bicarbonate (E) doesn't apply. N-acetylcysteine is critical.