ATI RN
Safety Pharmacology Across the Lifespan ATI Quizlet Questions
Question 1 of 5
A histamine and serotonin receptor antagonist sometimes used for treatment of intestinal hypermobility of carcinoid
Correct Answer: A
Rationale: The correct answer is A: Cyproheptadine. Cyproheptadine is a histamine and serotonin receptor antagonist, making it suitable for treating intestinal hypermobility of carcinoid tumors. Histamine and serotonin play a role in intestinal motility, and blocking their receptors can help alleviate symptoms. Summary of other choices: B: Ergonovine is a uterine stimulant and is not indicated for treating intestinal hypermobility. C: Loratadine is a selective histamine H1 receptor antagonist used for allergies, not for intestinal hypermobility. D: Promethazine is an antihistamine and antiemetic, but it is not commonly used for treating intestinal hypermobility associated with carcinoid tumors.
Question 2 of 5
A43-year-old woman complained to her physician of annoying daytime sleepiness. The woman, who was treated in the past with several drugs for generalized anxiety, had been receiving diazepam for the past month. One week ago, she started taking an over-the-counter preparation for seasonal allergic rhinitis. Which of the following drugs most likely precipitated the patient's daytime sleepiness?
Correct Answer: C
Rationale: Step-by-step rationale for why choice C (Diphenhydramine) is correct: 1. Diphenhydramine is a first-generation antihistamine known for causing sedation. 2. The patient was experiencing daytime sleepiness, a common side effect of diphenhydramine. 3. The combination with diazepam (a sedative) likely potentiated the sedative effects. 4. Loratadine (choice A) is a non-sedating antihistamine. 5. Prednisone (choice B) is a corticosteroid and not typically associated with sedation. 6. Zolpidem (choice D) is a sedative-hypnotic used for insomnia but not taken by the patient.
Question 3 of 5
The reasons determining bioavailability are:
Correct Answer: C
Rationale: Bioavailability depends on absorption extent and hepatic first-pass metabolism (Choice C), where liver metabolism reduces drug availability post-oral administration. Blood rheology (Choice A) is unrelated, dose/intakes (Choice B) are factors but not primary, and filtration (Choice D) affects excretion.
Question 4 of 5
The volume of distribution (Vd) relates:
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Metabolic transformation and conjugation usually results in an increase of a substance biological activity:
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.