Correct Answer: B

Rationale: The correct answer is B: IgM. IgM antibodies are the first type of antibodies produced in response to an infection, indicating an active or recent infection. In the case of a rubella virus infection in a fetus, IgM antibodies can be detected in the umbilical cord blood, confirming the presence of the virus. IgA antibodies are mainly found in mucosal areas, IgG antibodies indicate past infection or immunity, and IgD antibodies play a role in B cell activation but are not typically detected in this context.

Correct Answer: A

Rationale: The most probable diagnosis is A: Malaria. The patient's symptoms of periodic chills, high fever, and profuse sweating, along with living in Africa where malaria is endemic, strongly suggest malaria. The enlarged liver and spleen are consistent with malaria infection. The low erythrocyte count indicates hemolysis, a common feature of malaria. Spotted fever and sepsis do not typically present with the same pattern of symptoms and travel history as seen in this case. Haemolytic anaemia would not explain the patient's fever episodes and other symptoms. Therefore, based on the symptoms, travel history, and laboratory findings, malaria is the most likely diagnosis.

Correct Answer: D

Rationale: The correct answer is D: Fibers at the vertices of the icosahedron. Adenoviruses have fibers at the vertices of the icosahedron, which give them their distinctive pattern. These fibers help in attaching to host cells. Choices A, B, and C are incorrect because adenoviruses do not have a lipid envelope, helical capsid, or ssDNA. Adenoviruses have a non-enveloped icosahedral capsid and contain dsDNA. This makes choice D the correct answer as it specifically relates to the unique structural feature of adenoviruses.

Correct Answer: D

Rationale: The correct answer is D: BCG vaccination. BCG vaccination is recommended for individuals with a negative Mantoux test result, especially in countries where tuberculosis is prevalent. This vaccination can help provide protection against tuberculosis. Choice A is incorrect because repeating the Mantoux test in a month is unnecessary since the boy already had a negative reaction. Choice B is incorrect as serodiagnosis of tuberculosis is not the first-line approach for diagnosis, especially in this scenario. Choice C is incorrect because urgent isolation is not necessary based solely on the Mantoux test result. Isolation is typically reserved for individuals with active tuberculosis.

Correct Answer: B

Rationale: The correct answer is B: Gram negative coccobacillus. Bordetella pertussis, the causative agent of pertussis, is a gram-negative coccobacillus. This is because it is a small, rod-shaped bacterium that appears both as a bacillus (rod-shaped) and a coccus (spherical) shape. It does not retain the crystal violet stain in the Gram staining process, indicating its negative gram nature. Choice A is incorrect because pertussis is not a gram-positive bacillus. Choice C is incorrect because pertussis is not a long gram-negative rod-shaped bacterium. Choice D is incorrect as the other options do not accurately describe the morphology of Bordetella pertussis.