ATI RN
Genetic Pediatric Questions
Question 1 of 5
A cytogenetic diagnosis of chronic myeloid leukemia is made by identification of:
Correct Answer: D
Rationale: The Philadelphia chromosome (t(9;22)) is the diagnostic hallmark of CML.
Question 2 of 5
Which of the following are known to cause cancer?
Correct Answer: D
Rationale: All are carcinogenic: viruses (e.g., HPV), radiation (e.g., UV), and chemicals (e.g., asbestos).
Question 3 of 5
All of the following are correct except:
Correct Answer: D
Rationale: E is incorrect. Tumor suppressors are typically inactivated in cancer, not overexpressed.
Question 4 of 5
Which of the following is not a tumour suppressor gene?
Correct Answer: D
Rationale: RET is a proto-oncogene (gain-of-function in cancer); APC, NF1, RB1 are tumor suppressors.
Question 5 of 5
The presence of an extra digit is referred to as:
Correct Answer: D
Rationale: Polydactyly is the term for extra digits.