Correct Answer: B

Rationale: When treating tuberculosis, using a combination of multiple medications is crucial to reduce the risk of bacterial resistance. The use of four medications helps to target the bacteria from different angles, making it harder for them to develop resistance to the treatment. This approach is essential to ensure the effectiveness of the treatment regimen and to prevent the spread of drug-resistant strains of tuberculosis.

Correct Answer: D

Rationale: The expected outcome of Valproate therapy is a decrease in seizure activity. Valproate is commonly used in the treatment of epilepsy to help control and reduce seizure frequency.

Correct Answer: A

Rationale: Protamine sulfate is the antidote for Heparin. Heparin is an anticoagulant used to prevent blood clotting. Protamine sulfate works by binding to heparin, neutralizing its anticoagulant effects. Vitamin K is not the antidote for Heparin; it is used to reverse the effects of warfarin, another type of anticoagulant. Naloxone is an opioid antagonist used to reverse the effects of opioids, and Toradol is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief.

Correct Answer: A

Rationale: An INR of 4.0 is above the therapeutic range for a client on Warfarin, indicating an increased risk of bleeding. This finding requires immediate reporting to the provider for appropriate intervention to prevent complications associated with excessive anticoagulation.

Correct Answer: B

Rationale: Grapefruit juice affects carbamazepine metabolism and should be avoided. It can lead to increased levels of the medication, potentially causing toxicity. Monitoring carbamazepine blood levels and the complete blood count (CBC) is essential to ensure the medication's efficacy and safety. Carbamazepine can cause serious adverse effects like Stevens-Johnson syndrome, which can be life-threatening. Therefore, the client should promptly report any rash to the healthcare provider. Additionally, the client should be educated about potential central nervous system (CNS) side effects such as drowsiness or dizziness, and advised to avoid activities requiring alertness until these effects diminish.