A client metastatic ovarian cancer is prescribed cisplatin (Platinol). Before administering the first dose, the nurse reviews the client's medication history for drugs that may interact with cisplatin. Which drug may cause significant interactions when given concomitantly with cisplatin?

Correct Answer: D

Rationale: Amino glycosides, such as gentamicin or amikacin, can interact significantly with cisplatin, leading to increased risk of kidney damage or hearing loss. Both amino glycosides and cisplatin are known to have nephrotoxic and ototoxic effects independently. When combined, the risk of these side effects is potentiated, making it important to monitor renal function and hearing closely when these drugs are co-administered. Therefore, it is crucial to avoid the concomitant use of amino glycosides with cisplatin in order to prevent harmful drug interactions and reduce the risk of adverse effects in the client with metastatic ovarian cancer.

Correct Answer: C

Rationale: The major manifestation of nephrotic syndrome is edema. Nephrotic syndrome is a kidney disorder characterized by increased permeability of the glomerular filtration barrier, leading to excessive protein loss in the urine. This results in low levels of protein in the blood, particularly albumin, leading to a decrease in oncotic pressure. The decreased oncotic pressure causes fluid to accumulate in the interstitial spaces, leading to edema formation. Patients with nephrotic syndrome typically present with periorbital edema, pedal edema, and ascites due to the fluid redistribution in the body. Hematuria, hyperalbuminemia, and anemia are not typically the primary manifestations of nephrotic syndrome.

Correct Answer: A

Rationale: The correct choice is Pyridoxine. Levodopa is a precursor to dopamine and is commonly used in the treatment of Parkinson's disease. Pyridoxine, also known as vitamin B6, has been shown to reduce the effectiveness of Levodopa by accelerating its conversion to dopamine in the bloodstream before it reaches the brain. This reduces the amount of Levodopa available to provide therapeutic benefit in Parkinson's disease. It is important for patients taking Levodopa to be cautious about taking vitamin B6 supplements to avoid diminishing the efficacy of their medication.

Correct Answer: B

Rationale: A common initial reaction of parents to illness or injury and hospitalization in their child is fear. When a parent receives news that their child is unwell or requires hospitalization, it can trigger feelings of fear about the child's well-being, the seriousness of the situation, the treatment process, and the overall outcome. Fear of the unknown, concern for their child's pain and suffering, and worries about the future can all contribute to this initial reaction. It is a natural response for parents to be fearful in such situations as they navigate through the uncertainty and challenges associated with their child's illness or injury.

Correct Answer: C

Rationale: Hemophilia A, also known as classic hemophilia, is a genetic bleeding disorder caused by a deficiency or dysfunction of clotting factor VIII. Factor VIII is crucial for the blood clotting process, and its deficiency leads to prolonged bleeding episodes, even from minor injuries. Christmas disease, mentioned in the options, refers to Hemophilia B, which results from a deficiency in clotting factor IX, not factor VIII. Therefore, the disorder resulting from a deficiency of factor VIII is Hemophilia A.