ATI RN
Proctored Pharmacology ATI Questions
Question 1 of 9
A client has a new prescription for Ranitidine to treat peptic ulcer disease. Which of the following instructions should the nurse include?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 9
A client has a prescription for Acyclovir. Which of the following instructions should the nurse include?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 9
A healthcare provider is educating a client who has a prescription for Theophylline. Which of the following instructions should the healthcare provider include?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 9
Individuals who are slow acetylators (i.e. have a relatively low activity of hepatic N-acetyltransferase):
Correct Answer: D
Rationale: Slow acetylators have reduced hepatic N-acetyltransferase (NAT2) activity, affecting metabolism of drugs like hydralazine, isoniazid, and procainamide. In European Caucasians, prevalence is actually 50-60%, not 15-20%, making that statement inaccurate. Gold treatment side effects like thrombocytopenia or nephrotic syndrome aren't strongly linked to acetylation status, but rather to immune responses, so that's less relevant. Halothane hepatotoxicity relates to immune-mediated reactions or metabolites, not acetylation speed. Hydralazine, metabolized by NAT2, accumulates in slow acetylators, increasing risk of drug-induced lupus with antinuclear antibodies (ANA), a well-documented association. Agranulocytosis with clozapine isn't tied to acetylation but to idiosyncratic reactions. The ANA risk with hydralazine is the most accurate, reflecting its pharmacogenetic implications, critical for personalized dosing and monitoring.
Question 5 of 9
A client has a new prescription for Hydroxychloroquine to treat Lupus Erythematosus. Which of the following adverse effects should the nurse include in the teaching?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 6 of 9
Which drug type used to treat depression works by preventing enzymatic destruction of the neurotransmitter norepinephrine?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 7 of 9
A client has a new prescription for spironolactone. The client should be monitored for which of the following adverse effects?
Correct Answer: A
Rationale: Spironolactone is a potassium-sparing diuretic that can lead to hyperkalemia as an adverse effect. Hyperkalemia is characterized by elevated levels of potassium in the blood, which can be dangerous and lead to cardiac arrhythmias. Therefore, monitoring for signs and symptoms of hyperkalemia is crucial when a client is taking spironolactone.
Question 8 of 9
Which drug undergoes extensive first-pass hepatic metabolism?
Correct Answer: C
Rationale: Propranolol undergoes extensive first-pass metabolism in the liver. When administered orally, propranolol is extensively metabolized by the liver before reaching systemic circulation, leading to reduced bioavailability. This process is known as first-pass hepatic metabolism, which significantly affects the drug's effectiveness and necessitates higher oral doses compared to other routes of administration.
Question 9 of 9
A healthcare professional is preparing to administer Spironolactone to a client. Which of the following laboratory results should the professional review before administering this medication?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.