A child has been brought with intestinal obstruction due to clumping of round worms. Which of the following anthelmintics administered by intragastic tube can relax the ascarids and relieve the obstruction

Correct Answer: D

Rationale: Piperazine relaxes ascarids by paralyzing their muscles, relieving intestinal obstruction.

Correct Answer: C

Rationale: Amphotericin B, nystatin, and griseofulvin are antibiotics derived from fungi, whereas miconazole is a synthetic azole antifungal, not an antibiotic.

Correct Answer: C

Rationale: Nystatin, like amphotericin B, binds ergosterol in Candida cell membranes, altering permeability and causing cell death, while ketoconazole inhibits ergosterol synthesis.

Correct Answer: B

Rationale: Isoniazid inhibits mycolic acid synthesis in Mycobacterium tuberculosis by targeting InhA and KatG, disrupting cell wall formation, a key mechanism in TB treatment.

Correct Answer: D

Rationale: Pyrantel is the drug of choice for nematode (roundworm) infections like ascariasis, paralyzing worms by acting on their neuromuscular junctions.