A baby that was born 5 minutes earlier is tachypneic, tachycardic, and markedly cyanotic. A STAT echocardiogram confirms the presence of a cyanotic congenital cardiac defect. Which of the following defects would be consistent with the assessment findings?

Correct Answer: B

Rationale: Transposition of the great vessels is a cyanotic congenital heart defect where the aorta arises from the right ventricle and the pulmonary artery arises from the left ventricle. This results in two separate circulatory systems - one for oxygenated blood and another for deoxygenated blood. Due to this abnormal circulation, babies with transposition of the great vessels may present with severe cyanosis soon after birth. They can also develop tachypnea and tachycardia as compensatory mechanisms to maintain oxygen delivery. A STAT echocardiogram would confirm the diagnosis by showing the abnormal connection of the great vessels.

Correct Answer: C

Rationale: Methotrexate is a chemotherapy medication that is commonly used in the treatment of various types of cancers, including leukemia. Leukemia is a cancer of the blood and bone marrow that affects the white blood cells. Methotrexate works by interfering with the growth and division of cancer cells, thereby helping to slow down or stop the progression of the disease. It is not typically used to treat thalassemia, hemophilia, or sickle cell anemia, as these conditions are not cancers and require different types of treatment approaches.

Correct Answer: D

Rationale: Nephrosis, also known as nephrotic syndrome, is characterized by the presence of massive proteinuria (excretion of more than 3.5 grams of protein in the urine per day), hypoalbuminemia (low levels of albumin in the blood), and edema (swelling due to fluid retention). These are the hallmark clinical manifestations of nephrosis. Proteinuria results from damage to the glomerular filtration barrier, leading to the loss of proteins, particularly albumin, in the urine. Hypoalbuminemia occurs due to the excessive loss of albumin in the urine, leading to reduced oncotic pressure in the bloodstream. Edema develops as a result of decreased oncotic pressure, which causes fluid to leak from the blood vessels into the tissues, especially in the lower extremities and around the eyes. Other common manifestations of nephrosis may include hyperlipidemia, lipid

Correct Answer: D

Rationale: Brown adipose tissue (BAT) is specialized adipose tissue found in newborns and hibernating mammals, whose primary function is to generate heat through non-shivering thermogenesis. This heat generation is essential for maintaining body temperature in newborns, especially as they have a larger surface area-to-volume ratio, which results in greater heat loss compared to adults. BAT produces heat by metabolizing stored lipids and disrupting the normal process of cellular respiration, leading to the production of heat instead of ATP. The heat generated by BAT is then distributed throughout the body to help maintain a stable core body temperature in newborns, who are not yet able to regulate their body temperature as effectively as adults.

Correct Answer: D

Rationale: Nonpathologic cyanosis in newborns shortly after birth is typically seen in the mucous membranes, such as the lips and oral mucosa. This transient cyanosis is caused by the normal physiologic response of the newborn's immature circulatory system adjusting to extrauterine life. As oxygenation improves and blood circulation stabilizes, the cyanosis will usually resolve within the first few days after birth. It is important for healthcare providers to distinguish between pathologic and nonpathologic cyanosis in newborns to ensure appropriate management and monitoring.