A 9-month-old infant presents with history of early-onset jaundice and growth retardation; on examination there are cataracts, hepatosplenomegaly, and purpuric skin lesions; CBC revealed thrombocytopenia; echo study showed peripheral pulmonary artery stenosis. Of the following, the MOST likely diagnosis is

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Pediatric Infectious Disease Questions

Question 1 of 5

A 9-month-old infant presents with history of early-onset jaundice and growth retardation; on examination there are cataracts, hepatosplenomegaly, and purpuric skin lesions; CBC revealed thrombocytopenia; echo study showed peripheral pulmonary artery stenosis. Of the following, the MOST likely diagnosis is

Correct Answer: D

Rationale: Cataracts, purpura, thrombocytopenia, and pulmonary stenosis at 9 months point to congenital rubella (D), unlike syphilis (A), HSV (B), CMV (C), or toxoplasmosis (E) profiles.

Question 2 of 5

The drug of choice for treatment of congenital syphilis is

Correct Answer: A

Rationale: Penicillin (A) is the gold standard for congenital syphilis, effective against Treponema pallidum, per CDC guidelines.

Question 3 of 5

The mainstay of treatment for neonatal sepsis is

Correct Answer: C

Rationale: Ampicillin and gentamicin (C) cover GBS and gram-negatives, the mainstay for neonatal sepsis, per AAP guidelines.

Question 4 of 5

Sudden onset, short duration seizure that appears on day 1 to 3 of life in a well appearing infant that do not recur may be the result of

Correct Answer: C

Rationale: Benign familial seizures (C) present early, resolve quickly, and don’t recur in well infants, per genetic seizure patterns.

Question 5 of 5

In hypoxic-ischemic encephalopathy, refractory seizures begin

Correct Answer: A

Rationale: Refractory seizures in HIE start 12-24 hours (A) post-birth, reflecting early neuronal injury, per HIE timelines.

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