ATI RN
Endocrine Pharmacology Quiz Questions
Question 1 of 5
A 67-year-old man injures his shoulder in an ATV accident. Over-the-counter and prescription ibuprofen are unable to control the pain and swelling satisfactorily. The patient asks about glucocorticoid injections, so his doctor begins to explain the myriad effects of glucocorticoids in the body. How might glucocorticoids help this patient?
Correct Answer: B
Rationale: Glucocorticoids inhibit phospholipase \A_2, reducing prostaglandin and leukotriene synthesis, thus decreasing inflammation and pain in the shoulder.
Question 2 of 5
A week-old newborn male presents to clinic for a routine checkup. His birth history and delivery were uncomplicated. He is being breastfed and has had no difficulty feeding. The parents are concerned because he does not seem to have male genital characteristics. Physical examination reveals female external genitalia seen without a scrotum or descended testicles. What androgen is the patient lacking that is the cause of his condition?
Correct Answer: D
Rationale: DHT is critical for male external genitalia development; its absence (e.g., in 5alpha-reductase deficiency) results in female-appearing genitalia despite XY karyotype.
Question 3 of 5
An 18-year-old female with diabetes presents to the clinic for her annual visit. Over the past year, she has experienced daily nausea and occasional vomiting. She has learned that eating small amounts of food at a time helps to decrease the frequency of vomiting. She is diagnosed with diabetic gastroparesis and started on metoclopramide. What is a side effect of metoclopramide?
Correct Answer: D
Rationale: Metoclopramide, a prokinetic, can cause tardive dyskinesia, a serious movement disorder, with prolonged use.
Question 4 of 5
A 37-year-old man is found to have hypercholesterolemia during a routine checkup. The physician prescribes lovastatin and counsels the patient to make healthy dietary and lifestyle changes to keep his cholesterol under control. Two months later, he returns for a follow-up visit, and the physician discovers his LDL level remains virtually unchanged. He insists that he is taking the medication exactly as prescribed. The physician knows lovastatin is metabolized by the cytochrome P450 3A4. What else may he be using that would explain his condition?
Correct Answer: D
Rationale: St. John's wort induces CYP3A4, increasing lovastatin metabolism and reducing its efficacy, explaining unchanged LDL.
Question 5 of 5
A 27-year-old woman presents to clinic with infertility over the past 2 years. Her husband had a normal sperm analysis. She has also had weight gain and increased facial hair. Her labs show an increase in both her LH and FSH, with a ratio of LH:FSH of 2:1. What is the most appropriate medication to help her with her infertility?
Correct Answer: A
Rationale: Clomiphene induces ovulation in PCOS (suggested by LH:FSH >2:1, hirsutism), addressing her infertility.