A 65-year-old man with non-insulin-dependent diabetes mellitus presents to his primary care physician for follow-up. He is currently managed with glyburide. His weight has increased from a baseline of 195lb to 230lb during the past year. He walks approximately 30~min every other day throughout the year and eats three balanced meals per day. What is the most likely explanation for these findings?

A 65-year-old man with non-insulin-dependent diabetes mellitus presents to his primary care physician for follow-up. He is currently managed with glyburide. His weight has increased from a baseline of 195lb to 230lb during the past year. He walks approximately 30~min every other day throughout the year and eats three balanced meals per day. What is the most likely explanation for these findings?

A 19-year-old woman who was intoxicated at a party finds that she had nonconsenting sexual intercourse after awakening without clothes on the following morning. She presents to the ambulatory care clinic and is administered with postcoital contraception. She is still very concerned that she may become pregnant. An estimation of the risk of pregnancy in this scenario is approximately

A 44-year-old woman with systemic lupus erythematosus presents to her primary care physician for follow-up. She is currently being managed with an oral glucocorticoid agent. The most likely mechanism of action of this medication involves which of the following?

A 23-year-old male college graduate student with a history of asthma presents to the ambulatory care clinic for follow-up. He uses a \beta_3-agonist via inhaler when he has an attack. The treating physician should be alert to which of the following possible findings on examination and laboratory studies?

A 37-year-old woman who is obese with hyperglycemia complains of polyuria and polydipsia. Her physician prescribes glipizide to help control her blood sugar. After a few days of taking glipizide, she develops a pruritic rash. The physician prescribes a different drug. In light of her rash and in the absence of other contraindications, which of the following drugs would be safe for her to take?