ATI RN
Pharmacology Across the Lifespan Questions
Question 1 of 5
A 65-year-old man with long-standing schizophrenia has been taking an antipsychotic agent since his diagnosis of schizophrenia at age 19 years. He has been in and out of psychiatric hospitals for most of his adult life. Long-term adverse effects of these agents may include which of the following?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 2 of 5
A 39-year-old woman with chronic migraine headaches manages her condition with ibuprofen 200 mg. Most days, she does well with 200 to 400 mg. Adverse reactions to this therapy include which of the following?
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
A 33-year-old woman patient needs to be anesthetized before a dilation and curettage for abnormal uterine bleeding. Her anesthesia is induced initially with an inhaled, nonflammable anesthetic that contains no halogenated carbons. Of the following, which agent best fits this description?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
A 20-year-old woman comes to the emergency department after ingesting at least 30 tablets of an unknown drug. Initial physical examination shows no abnormalities. Thirty-six hours later, serum AST activity is 1500 U/L, and serum ALT activity is 2000 U/L. The drug this patient ingested is most likely which of the following?
Correct Answer: A
Rationale: Elevated AST and ALT (1500 and 2000 U/L) 36 hours post-ingestion indicate acute liver injury, characteristic of acetaminophen overdose. Acetaminophen is metabolized to NAPQI, which depletes glutathione and causes centrilobular hepatic necrosis if untreateAspirin causes salicylism (tinnitus, acidosis), chlorpheniramine sedation, ibuprofen GI upset, and prednisone (E) adrenal suppression—none primarily cause delayed hepatotoxicity like this.
Question 5 of 5
A 47-year-old woman is admitted to the hospital for treatment of pneumococcal pneumoniTreatment with gentamicin and penicillin is initiateWithin 10 minutes of the administration of antimicrobial therapy, her respirations increase to 30/min, and blood pressure decreases to 80/40 mm Hg. Epinephrine, antihistamine, and corticosteroid therapy is starteHer condition improves slowly during the next 2 hours. Her antimicrobial therapy is changed to gentamicin only, and her condition continues to improve. Administration of which of the following types of drugs is most likely to cause a similar adverse reaction in this patient?
Correct Answer: A
Rationale: The acute reaction (tachypnea, hypotension) post-penicillin, relieved by epinephrine and antihistamines, indicates an anaphylactic response to penicillin, a beta-lactam. Cephalosporins (A), also beta-lactams, have cross-reactivity (5-10%) with penicillin allergies, risking a similar reaction. Macrolides (B), quinolones (C), and tetracyclines lack this structural similarity and rarely cause anaphylaxis.