A 65 y.o. woman complains of complicated mouth opening following foot trauma 10 days ago. Next day she ate with difficulties, there were muscles tension of back, the back of the head and abdomen. On the third day there was tension of all muscle groups, generalized convulsions every 10-15 min. What is the most probable diagnosis?

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Microbiology An Introduction 13th Edition Test Bank Questions

Question 1 of 5

A 65 y.o. woman complains of complicated mouth opening following foot trauma 10 days ago. Next day she ate with difficulties, there were muscles tension of back, the back of the head and abdomen. On the third day there was tension of all muscle groups, generalized convulsions every 10-15 min. What is the most probable diagnosis?

Correct Answer: A

Rationale: The most probable diagnosis is Tetanus (Choice A) based on the symptoms described. Tetanus is characterized by muscle stiffness, difficulty opening the mouth (trismus), muscle spasms, and convulsions. The progression of symptoms from muscle tension to generalized convulsions every 10-15 min is classic for tetanus. Tetania (Choice B) is similar but typically presents with more subtle muscle contractions rather than convulsions. Meningoencephalitis (Choice C) presents with fever, headache, and altered mental status, not the muscle symptoms described. Hemorrhagic stroke (Choice D) presents with sudden onset neurological deficits like weakness or sensory changes, not the muscle symptoms described.

Question 2 of 5

A bacteriological laboratory received a sample of dried fish from an outbreak of food poisoning. Inoculation of the sample on Kitt-Tarozzi medium revealed microorganisms resembling tennis racket. These microorganisms are causative agents of the following disease:

Correct Answer: B

Rationale: Step 1: The description of microorganisms resembling tennis racket indicates Corynebacterium diphtheriae, the causative agent of diphtheria. Step 2: Diphtheria is a bacterial infection that can cause severe respiratory and systemic symptoms. Step 3: Botulism is caused by Clostridium botulinum, not tennis racket-shaped microorganisms. Step 4: Typhoid fever is caused by Salmonella typhi, which does not resemble tennis rackets. Step 5: Salmonellosis is caused by various Salmonella species, which also do not have the described tennis racket appearance.

Question 3 of 5

A patient suffering from syphilis was prescribed a drug the action of which based upon disturbed generation of murein leading to death of the causative agent. What drug is it?

Correct Answer: A

Rationale: The correct answer is A: Benzylpenicillin sodium salt. Benzylpenicillin is a beta-lactam antibiotic that inhibits the synthesis of bacterial cell walls by disrupting the formation of murein (peptidoglycan), leading to bacterial cell death. This mechanism specifically targets the causative agent of syphilis, Treponema pallidum. - Choice B: Bijochinol is not a known drug used to treat syphilis. - Choice C: Ciprofloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA replication and is not the first-line treatment for syphilis. - Choice D: Azithromycin is a macrolide antibiotic that interferes with bacterial protein synthesis and is commonly used to treat other infections but is not the preferred treatment for syphilis.

Question 4 of 5

A 52-year-old patient has the following diagnosis: systemic amebiasis with involvment of intestines, liver, lungs. What drug should be prescribed?

Correct Answer: A

Rationale: The correct answer is A: Metronidazole. It is the drug of choice for treating systemic amebiasis due to its high efficacy against Entamoeba histolytica. Metronidazole is well-absorbed, reaches therapeutic levels in the intestines, liver, and lungs, making it effective in treating the multi-organ involvement in this case. Choice B: Quiniofone is not a recommended treatment for amebiasis. Choice C: Tetracycline is not the first-line treatment for systemic amebiasis. Choice D: Quingamine is not a recognized drug for treating amebiasis.

Question 5 of 5

A businessman came to India from South America. On examination the physician found that the patient was suffering from sleeping-sickness. What was the way of invasion?

Correct Answer: B

Rationale: The correct answer is B: As a result of mosquito's bites. Sleeping sickness, also known as African trypanosomiasis, is caused by the parasite Trypanosoma transmitted by tsetse flies, not mosquitoes. Tsetse flies are primarily found in Africa, not South America. Choice A is incorrect as bug bites do not transmit sleeping sickness. Choice C is incorrect as contaminated fruits and vegetables do not transmit the disease. Choice D is incorrect as dirty hands do not play a role in the transmission of sleeping sickness.

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