A 63-year-old female presents to clinic for a diabetes follow-up. She has been taking metformin for 3 years now, but her blood sugars have not been well controlled over the past year. Her average morning fasting blood sugar is 165mg\dL, and her 2-h postprandial is 205mg\dL. Glimepiride is added to her regimen. What is the mechanism of action of glimepiride?

A 63-year-old female presents to clinic for a diabetes follow-up. She has been taking metformin for 3 years now, but her blood sugars have not been well controlled over the past year. Her average morning fasting blood sugar is 165mg\dL, and her 2-h postprandial is 205mg\dL. Glimepiride is added to her regimen. What is the mechanism of action of glimepiride?

A 57-year-old man was recently diagnosed with Type-2 diabetes mellitus and placed on a medication. He began having myalgias and feeling sick and later developed respiratory distress, so he went to the hospital. His pH was 7.2, and he had elevated blood lactate levels. Which drug is likely causing his problem?

A 52-year-old overweight woman presents to the clinic for a diabetes management. She had not been doing well controlling her blood sugars with metformin. Her last hemoglobin \A_{\lc was 13.4%, despite her taking her medication every day. The physician decides to start her on a long-acting insulin that is injected only once a day for better glucose control. Also, he wants the insulin to have a minimal risk of hypoglycemia. What is the most likely medication given to this patient?

Five patients with elevated cholesterol present to the ambulatory care clinic for treatment of abnormalities of cholesterol. Which of the following patients would best benefit from treatment with an HMG-CoA reductase inhibitor?

A 45-year-old woman with diabetes and hypertension presents to the primary care clinic with a cough. The nonproductive cough started about 2 weeks ago. She has not had a fever, congestion, or been around any sick contacts. However, she was recently started on lisinopril. The physician decides to switch her to losartan, and the patient reports that her cough has ceased. What is the mechanism of action of losartan?