ATI RN
Chemotherapy drugs Questions
Question 1 of 5
A 54-year-old woman with a history of left-sided breast cancer has been in remission for 5 years following paclitaxel therapy coupled with surgical resection. She has now noticed a new lump in her left breast close to where the original tumor was excised. A biopsy reveals recurring cancer. After talking with her physician, she decided to undergo more chemotherapy. Her physician prescribes a drug, which interferes with microtubules. Which is a chemotherapy drug that disrupts the microtubule assembly?
Correct Answer: D
Rationale: Vincristine disrupts microtubule assembly by binding tubulin, preventing mitotic spindle formation, effective against recurrent breast cancer.
Question 2 of 5
A 61-year-old man with osteoarthritis comes to the clinic for follow-up. His arthritis has been worsening over the past year. He has pain constantly throughout the day. He reports the only medication that was effective for him was celecoxib, which was pulled from the market. He is willing to try anything that will improve his pain at this point. What side effect is the reason for the removal of celecoxib from the market?
Correct Answer: D
Rationale: Celecoxib, a COX-2 inhibitor, was associated with an increased risk of thrombosis (e.g., myocardial infarction, stroke) due to unbalanced prostacyclin/thromboxane effects, leading to its market withdrawal in some contexts.
Question 3 of 5
A 25-year-old man with multiple sexual partners begins to have flulike symptoms. He visits his doctor who recommends an HIV screening test based on his history. He is found to have an HIV infection and begins a drug regimen. Which of the following works by inhibiting fusion of the virion with T cells?
Correct Answer: D
Rationale: Maraviroc inhibits HIV fusion by blocking the CCR5 co-receptor on T cells, preventing viral entry, distinct from other HAART drugs targeting replication steps.
Question 4 of 5
A 26-year-old man with schizophrenia takes daily codeine for no apparent reason. He does not have issues with upper respiratory disease. Which of the following effects would be least likely to be exhibited by this patient?
Correct Answer: D
Rationale: Codeine, an opioid, causes analgesia, euphoria, sedation, and cough suppression (not dry cough), but tinnitus is not a typical effect, making it least likely.
Question 5 of 5
A 28-year-old man who suffered a crush injury to his lumbar spine (L4 and L5) with disc herniation is managed with meperidine for pain control. He has been taking this medication for 6 months. In addition to pain relief, which of the following other effects is possible?
Correct Answer: C
Rationale: Long-term meperidine use can lead to neurotoxicity from normeperidine accumulation, causing seizures or tremors, distinct from typical opioid effects like constipation.