ATI RN
Intro to Pharmacology ATI Questions
Question 1 of 5
A 52-year-old man with asthma treated with a β2 agonist via inhaler has been having difficulty with therapy because of persistent changes in blood pressure, nausea, vomiting, and hypomagnesemia. Which of the following medications would be best for this patient?
Correct Answer: D
Rationale: β2-agonist side effects (BP changes, nausea, hypomagnesemia) suggest overuse. Ipratropium , an anticholinergic bronchodilator, avoids these. Options , , persist with β2-agonists, risking side effects. Epinephrine (E) worsens them. Ipratropium's different mechanism improves asthma control safely.
Question 2 of 5
Ingestion of methanol in wood spirits would cause which of the following to happen?
Correct Answer: A
Rationale: Methanol, a toxic alcohol, is metabolized by alcohol dehydrogenase into formaldehyde, then by aldehyde dehydrogenase into formic acid, causing severe metabolic acidosis and blindness via optic nerve damage. This initial step—formation of formaldehyde—is the critical toxic event, distinguishing methanol poisoning from ethanol's safer metabolism. Nephrotoxicity isn't primary; formic acid affects mitochondria and eyes more. Hypotension and vomiting occur secondary to acidosis but aren't the defining process. Glycolic acid is a metabolite of ethylene glycol, not methanol. Methanol inhibits aldehyde dehydrogenase minimally; its danger lies in metabolite accumulation. Formaldehyde production initiates the cascade, making it the most direct and accurate consequence of methanol ingestion.
Question 3 of 5
The client receives nystatin (Nilstat) for a fungal infection in the mouth. The nurse plans to do medication education prior to discharge. What will the best plan by the nurse include?
Correct Answer: A
Rationale: Nystatin is an antifungal used for oral candidiasis (thrush), and its effectiveness depends on proper administration. For oral infections, the medication must remain in contact with the affected mucosal surfaces as long as possible. Dissolving the tablet in the mouth ensures prolonged exposure to the fungus, allowing it to act locally before swallowing, which is the recommended method for tablets or lozenges. Using a straw might apply to suspensions but isn't standard for preventing discoloration, which isn't a primary concern with nystatin. Crushing and mixing with juice alters the drug's intended delivery, reducing contact time with the infection site. Swallowing whole bypasses the oral mucosa entirely, rendering it ineffective for thrush. Thus, choice A aligns with nystatin's mechanism, ensuring optimal therapeutic outcomes through direct mucosal contact.
Question 4 of 5
The physician orders penicillin for a female client who has a sinus infection. What is a priority question to ask the client prior to administering the medication?
Correct Answer: A
Rationale: Penicillin, a beta-lactam antibiotic, is generally safe (Category B) but requires pregnancy status clarification before administration. Pregnancy alters drug metabolism and dosing, and while penicillin poses minimal fetal risk, confirming status ensures no hypersensitivity or rare contraindications are overlooked, prioritizing maternal and fetal safety. Future pregnancy plans are less immediate, affecting long-term considerations, not current use. Breastfeeding matters due to minimal excretion in milk, but it's secondary to current pregnancy. Birth control interaction is negligible with penicillin, unlike other antibiotics. Asking 'Are you pregnant?' addresses the most urgent safety concern, aligning with nursing's role in preventing adverse outcomes, making A the priority question before initiating therapy.
Question 5 of 5
The client is receiving warfarin (Coumadin) for a deep vein thrombosis. Which food should the nurse instruct the client to avoid in large amounts?
Correct Answer: A
Rationale: Warfarin, an anticoagulant, inhibits vitamin K-dependent clotting factors. Spinach is high in vitamin K, which can counteract warfarin's effect, reducing its efficacy and increasing clot risk if consumed in large amounts. The nurse must instruct avoidance to maintain therapeutic INR levels. Potatoes and bananas have minimal vitamin K and don't significantly affect warfarin. Chicken is protein-rich, not vitamin K-rich, posing no issue. Consistent vitamin K intake is key, but large amounts of spinach could destabilize anticoagulation, risking thrombus progression. This aligns with warfarin's pharmacodynamics, where dietary education prevents therapeutic failure. Potatoes, bananas, and chicken lack this interaction, making spinach the priority to limit. Thus, A is the correct choice, ensuring the client understands how to support treatment efficacy and safety through diet management.