A 5-year-old girl has been developed type 1 diabetes mellitus 6 months ago. She is on intensive control using multiple daily injections of insulin. A recent blood testing of HgbA1c is 6.5%. Of the following, the MOST frequent complication that may be encountered at this age is

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Pediatric Endocrine System Questions

Question 1 of 5

A 5-year-old girl has been developed type 1 diabetes mellitus 6 months ago. She is on intensive control using multiple daily injections of insulin. A recent blood testing of HgbA1c is 6.5%. Of the following, the MOST frequent complication that may be encountered at this age is

Correct Answer: A

Rationale: Intensive insulin therapy in young children often leads to recurrent hypoglycemia due to tight control (HgbA1c 6.5%), variable eating, and activity patterns. Hyperglycemia (B), weight loss (C), candidiasis (D), and UTIs (E) are less frequent with good control.

Question 2 of 5

Thyroid disorders consist of a variety of diseases that require different treatment according to the cause. Of the following, the thyroid disorder that does not require treatment is

Correct Answer: D

Rationale: Congenital thyroxine-binding globulin deficiency affects binding protein levels but not thyroid function, requiring no treatment, unlike hypothyroidism (A), cretinism (B), thyroiditis (C), or hyperthyroidism (D), which impair gland function.

Question 3 of 5

Rickets is defined as decreased bone mineralization in growing children. Hypocalcemia may accompany rickets. Of the following, the condition that causes hypocalcemia rather than rickets is

Correct Answer: C

Rationale: Primary hypoparathyroidism causes hypocalcemia without defective bone mineralization (rickets), unlike vitamin D deficiency (A), biliary atresia (B), renal failure (D), and hypophosphatemia (E), which impair mineralization.

Question 4 of 5

An ACTH-secreting pituitary microadenoma resulting in bilateral adrenal hyperplasia is termed Cushing disease; this should be distinguished from Cushing syndrome due to various causes. Of the following, the BEST test that helps to differentiate between Cushing disease and Cushing syndrome is

Correct Answer: A

Rationale: Children with stage 5 CKD (ESRD) are typically treated with either dialysis or renal transplantation. A 24-hour urinary cortisol excretion helps identify excess cortisol production, a key step in differentiating Cushing disease (pituitary-driven) from other Cushing syndrome causes, though high-dose dexamethasone (C) is often used later for confirmation.

Question 5 of 5

Nocturnal enuresis is best described as

Correct Answer: B

Rationale: Nocturnal enuresis is the involuntary loss of urine during sleep, treatable with behavioral strategies or medications like anticholinergics or DDAVP in selected cases.

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