A 5-year-old boy presented with history of frequent blood transfusion since the end of the first year of life, he has a similarly affected older sibling. On examination: he is pale and jaundiced, with frontal bossing and enlarged liver and spleen. Of the following, the MOST likely diagnosis is

A 5-year-old boy presented with history of frequent blood transfusion since the end of the first year of life, he has a similarly affected older sibling. On examination: he is pale and jaundiced, with frontal bossing and enlarged liver and spleen. Of the following, the MOST likely diagnosis is

The earliest response to oral iron, in iron deficiency anemia is

A feature that signifies β-thalassemia minor is

A challenging differential diagnosis of Diamond-Blackfan syndrome is

A 7-year-old apparently healthy boy presented to the outpatient clinic with mild pallor and slight yellowish discoloration of sclera since early childhood, family was reluctant to seek medical consultation. On examination, he had palpable spleen in addition to pallor and jaundice. His uncle had a history of repeated blood transfusions during childhood that was relieved with splenectomy. Of the following, the MOST likely diagnosis at this stage is