A 49-year-old man with manic depression has been maintained on lithium for long-term therapy. However, because of worsening of symptoms, he is placed on ziprasidone. The patient must be warned about which of the following adverse effects?

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: A

Rationale: Acute gout attacks require rapid inflammation reduction. Colchicine (choice B) disrupts microtubule function, reducing neutrophil activity. Indomethacin (choice C), an NSAID, inhibits COX, lowering prostaglandin levels. Glucocorticoids (choice D) suppress inflammation broadly. Allopurinol (choice A), a xanthine oxidase inhibitor, lowers uric acid long-term but doesn't address acute inflammation, making it the exception. This distinction guides acute versus chronic gout management.

Correct Answer: A

Rationale: Colchicine (choice B) treats acute gout by reducing inflammation, Allopurinol (choice C) lowers uric acid long-term, and Sulphinpyrazone (choice D) promotes urate excretion. Thiazide diuretics (choice A) increase uric acid retention, worsening gout, making them the exception. This distinguishes gout management from contraindicated drugs.

Correct Answer: D

Rationale: Flurazepam (choice A), Triazolam (choice B), and Chlordiazepoxide (choice C), all benzodiazepines, initiate sleep via GABAa potentiation, differing in duration (long, short, intermediate). ‘All of the above' (choice D) is correct, as each is a hypnotic, tailored to insomnia needs, highlighting benzodiazepine versatility.

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.