ATI RN
Effects of Pharmacological Treatments on Clients Across a Lifespan Questions
Question 1 of 5
A 49-year-old man with hypertension comes to the physician for a follow-up examination. At his last visit 2 months ago, his serum total cholesterol concentration was 320 mg/dL. He then began a low-cholesterol diet. His blood pressure is 145/95 mm Hg. Physical examination shows no other abnormalities. Serum studies show a total cholesterol concentration of 310 mg/dL. Kidney and liver function test results are within normal limits. The most appropriate pharmacotherapy for this patient is a drug that has which of the following mechanisms of action?
Correct Answer: B
Rationale: Persistent hypercholesterolemia (310 mg/dL) despite diet indicates a need for a statin, which inhibits HMG-CoA reductase (E), reducing hepatic cholesterol synthesis and upregulating LDL receptors to lower serum cholesterol. PPAR activation is for fibrates (triglycerides), VLDL reduction for niacin, bile acid sequestration for resins, and cholesterol absorption inhibition for ezetimibe—statins are most effective for LDL here.
Question 2 of 5
Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized:
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
For the calculation of the volume of distribution (Vd) one must take into account:
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
In case of liver disorders accompanied by a decline in microsomal enzyme activity the duration of action of some drugs is:
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
An agonist is a substance that:
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.