ATI RN
ATI Capstone Pharmacology Assessment 2 Quizlet Questions
Question 1 of 5
A 48-year-old woman with 2-year history of rheumatoid arthritis has not had sufficient relief with methotrexate alone. Her physician prescribes a biologic TNF-α inhibitor that consists of a recombinant human IgG fused to TNF-α receptor. Which of the following drugs is this?
Correct Answer: C
Rationale: Rheumatoid arthritis (RA) progression despite methotrexate warrants a TNF-α inhibitor. The description-recombinant human IgG fused to TNF-α receptor-points to Etanercept . Adalimumab and Golimumab are monoclonal antibodies against TNF-α, not receptor fusions. Certolizumab is a PEGylated Fab fragment, not IgG-based. Etanercept , a fusion protein, binds TNF-α, neutralizing it, and matches the question's structure. Infliximab (E) is a chimeric antibody. Etanercept's unique receptor-IgG design distinguishes it, effectively reducing RA inflammation by sequestering TNF-α, a key cytokine, making it the precise answer here.
Question 2 of 5
Regarding antibiotic resistance:
Correct Answer: B
Rationale: Beta-lactamase isn't the primary resistance mechanism in pneumococci (PBP alteration is), so that's false. Penicillin's poor penetration into gram-negative bacteria due to outer membranes is a true statement, a common resistance factor. Altered penicillin-binding proteins (PBPs) drive pneumococcal resistance, not the main general mechanism, though true in context. Methicillin resistance in Staph (MRSA) is due to mecA gene producing altered PBPs, not just beta-lactamase, so that's false. Penetration issues in gram-negatives are a fundamental barrier, guiding beta-lactam design like piperacillin.
Question 3 of 5
As you are preparing morning medications, the patient says, 'I have had loose stools all night long.' Your patient has scheduled docusate at 0900. What is the priority action?
Correct Answer: A
Rationale: Docusate is a stool softener used to prevent constipation. If the patient is already experiencing loose stools, administering docusate could exacerbate the condition, leading to diarrhea or dehydration. The nurse should hold the medication and inform the healthcare provider to reassess the need for docusate. Increasing the IV flow rate (C) or the dose (D) is inappropriate in this situation.
Question 4 of 5
Allopurinol (Zyloprim) is prescribed for a client for the treatment of gout. And the nurse is providing medication instructions. The nurse tells the client to?
Correct Answer: B
Rationale: Allopurinol should be taken with food to reduce gastrointestinal irritation. Limiting vitamin C intake is advised because it can increase uric acid levels, counteracting the drug's effects. A rash is not a normal side effect and may indicate a hypersensitivity reaction, requiring immediate medical attention. The therapeutic effects of allopurinol are not immediate and may take weeks to become apparent. Proper patient education is essential to ensure adherence and safety.
Question 5 of 5
A 5-year-old African American patient has been admitted to the pediatric intensive care unit with pheochromocytoma. The physician has ordered phentolamine. The nurse knows that the other indication for phentolamine is what?
Correct Answer: B
Rationale: Phentolamine (Regitine) is used for the prevention of cell death and tissue sloughing after extravasation of intravenous norepinephrine or dopamine, and severe hypertension reactions caused by manipulation of the pheochromocytoma before and during surgery; diagnosis of pheochromocytoma. Phentolamine would not be indicated for treatment of migraine headaches, life-threatening arrhythmias, or heart failure. The nurse should understand the indications for phentolamine to ensure safe and effective administration.