A 45-year-old woman with chronic anxiety presents to her primary care physician for follow-up. She currently takes Librium 10 mg three times per day. Important warning considerations for use of this medication include which of the following?

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: C

Rationale: Celecoxib (choice C) selectively inhibits COX-2, reducing inflammation with less GI irritation than non-selective NSAIDs like Aspirin (choice A) and Diclofenac (choice B), which inhibit both COX-1 and COX-2. Paracetamol (choice D) has weak COX inhibition, primarily COX-3, and lacks significant anti-inflammatory action. Celecoxib's selectivity minimizes COX-1-related side effects, making it preferable in patients at risk for GI issues, a key advancement in NSAID therapy.

Correct Answer: C

Rationale: Acetaminophen (choice C) is proposed to inhibit COX-3 (a COX-1 variant) in the CNS, explaining its antipyretic and analgesic effects with minimal anti-inflammatory action. Acetylsalicylic acid (choice A) and Diclofenac (choice B) inhibit COX-1 and COX-2, while Celecoxib (choice D) targets COX-2. Acetaminophen's selectivity distinguishes its mechanism, key for fever and pain management.

Correct Answer: A

Rationale: Carbidopa (choice A) inhibits dopa decarboxylase peripherally, preventing L-DOPA breakdown, enhancing CNS delivery in Parkinson's. It doesn't cross the BBB (choice B), reduces L-DOPA dose needs (choice C incorrect), and decreases peripheral metabolism (choice D incorrect). This correct statement underscores its adjunctive role.

Correct Answer: D

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.